Multimodal Anti-tumor Approaches Combined with Immunotherapy to Overcome Tumor Resistance in Esophageal and Gastric Cancer

Anticancer Research
Louisa BolmDamian J Hussey

Abstract

Upper gastrointestinal malignancies are associated with a high disease burden worldwide, and esophageal and gastric cancers represent the most common entities. Given a lack of early characteristic symptoms and potent screening instruments, the majority of patients present with advanced disease at the time of diagnosis. Complete surgical resection is a first-line curative option, and multimodal approaches involving chemotherapy and radiotherapy further improve patient prognosis. However, response to standard adjuvant and neoadjuvant treatments remains low, and new strategies are warranted to increase tumor control rates. Immunotherapy is emerging in various cancer entities and may be successfully combined with standard therapeutic regimens to improve patient outcome. For the purpose of this review we aimed to assess combined approaches of immunotherapy and standard treatment options such as chemotherapy, radiotherapy and surgery. Current trials evaluating multimodal approaches with immunotherapy in esophageal and gastric cancer are evaluated.

Citations

Dec 4, 2019·Oncology Letters·Luhong YangHuafeng Wang
Apr 7, 2020·Current Pharmaceutical Design·Qi TangHanmei Li
Oct 16, 2018·Frontiers in Endocrinology·Raffaele Frazzi
Feb 16, 2020·Pharmaceutical Research·Kevin Roe
Oct 2, 2019·Frontiers in Pharmacology·Jian-Ge QiuBing-Hua Jiang
Aug 21, 2020·Current Topics in Medicinal Chemistry·Simon N MbuguaMartin O Onani

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