Multimodal Connectomics in Psychiatry: Bridging Scales From Micro to Macro

Biological Psychiatry : Cognitive Neuroscience and Neuroimaging
Lianne H Scholtens, M P van den Heuvel

Abstract

The human brain is a highly complex system, with a large variety of microscale cellular morphologies and macroscale global properties. Working at multiple scales, it forms an efficient system for processing and integration of multimodal information. Studies have repeatedly demonstrated strong associations between modalities of both microscales and macroscales of brain organization. These consistent observations point toward potential common organization principles where regions with a microscale architecture supportive of a larger computational load have more and stronger connections in the brain network on the macroscale. Conversely, disruptions observed on one organizational scale could modulate the other. First neuropsychiatric micro-macro comparisons in, among other conditions, Alzheimer's disease and schizophrenia, have, for example, shown overlapping alterations across both scales. We give an overview of recent findings on associations between microscale and macroscale organization observed in the healthy brain, followed by a summary of microscale and macroscale findings reported in the context of brain disorders. We conclude with suggestions for future multiscale connectome comparisons linking multiple scales and modalit...Continue Reading

Citations

Dec 10, 2019·PLoS Computational Biology·Richard F BetzelDanielle S Bassett
May 28, 2019·Nature Reviews. Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Feb 11, 2019·Brain Structure & Function·Miguel Ángel García-CabezasHelen Barbas
Apr 26, 2019·ELife·Hugo Schnack

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