Multimodal cortical and hippocampal prediction of episodic-memory plasticity in young and older adults

Human Brain Mapping
Anne Cecilie Sjøli BråthenKristine B Walhovd

Abstract

Episodic memory can be trained in both early and late adulthood, but there is considerable variation in cognitive improvement across individuals. Which brain characteristics make some individuals benefit more than others? We used a multimodal approach to investigate whether volumetric magnetic resonance imaging (MRI) and resting-state functional MRI characteristics of the cortex and hippocampus, brain regions involved in episodic-memory function, were predictive of cognitive improvement after memory training. We hypothesized that these brain characteristics would differentially predict memory improvement in young and older adults, given the vulnerability of cortical regions as well as the hippocampus to healthy aging. Following structural and resting-state activity magnetic resonance scans, 50 young and 76 older participants completed 10 weeks of strategic episodic-memory training. Both age groups improved their memory performance, but the young adults more so than the older. Vertex-wise analyses of cortical volume showed no significant relation to memory benefit. When analyzing the two age groups separately, hippocampal volume was predictive of memory improvement in the group of older participants only. In this age group, the ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Jul 11, 2001·Neurobiology of Aging·T L JerniganJ R Hesselink
Sep 5, 2001·Nature Reviews. Neuroscience·R L Buckner, M E Wheeler
Feb 1, 1957·Journal of Neurology, Neurosurgery, and Psychiatry·W B SCOVILLE, B MILNER
Sep 27, 2003·Alzheimer Disease and Associated Disorders·Timothy A Salthouse
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lars NybergLars Bäckman
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Cindy LustigRandy L Buckner
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Apr 1, 2004·Cerebral Cortex·David H SalatBruce Fischl
Jun 29, 2004·NeuroImage·F SégonneB Fischl
Oct 27, 2004·NeuroImage·Bruce FischlAnders M Dale
Jul 12, 2005·Neurobiology of Aging·Kristine B WalhovdBruce Fischl
Aug 15, 2006·Neuroscience and Biobehavioral Reviews·Sari JonesLars Bäckman
Oct 20, 2006·Neurobiology of Aging·Daniel L GreenbergRanga R Krishnan
Oct 24, 2007·Experimental Psychology·Barbara CarrettiRossana De Beni
Dec 7, 2007·Neuron·Jessica R Andrews-HannaRandy L Buckner
Dec 8, 2007·Cerebral Cortex·J S DamoiseauxS A R B Rombouts
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Oct 8, 2008·Neurobiology of Aging·K B WalhovdUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 3, 2009·Neurobiology of Aging·Kristine B WalhovdAnders M Fjell
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anders M FjellAnders M Dale
Jan 16, 2010·AJNR. American Journal of Neuroradiology·K B WalhovdUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 2, 2010·Neuron·Jessica R Andrews-HannaRandy L Buckner
Jun 29, 2010·NeuroImage·Andreas EngvigKristine B Walhovd
Jul 17, 2010·NeuroImage·E A MurphyUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 20, 2010·NeuroImage·Martin ReuterBruce Fischl
Aug 21, 2010·Frontiers in Aging Neuroscience·Florian SchmiedekUlman Lindenberger

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Feb 27, 2020·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Anne Cecilie Sjøli BråthenKristine B Walhovd

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