Multimodal μCT/μMR based semiautomated segmentation of rat vertebrae affected by mixed osteolytic/osteoblastic metastases

Medical Physics
Seyed-Parsa HojjatC M Whyne

Abstract

Multimodal microimaging in preclinical models is used to examine the effect of spinal metastases on bony structure; however, the evaluation of tumor burden and its effect on microstructure has thus far been mainly qualitative or semiquantitative. Quantitative analysis of multimodality imaging is a time consuming task, motivating automated methods. As such, this study aimed to develop a low complexity semiautomated multimodal μCT/μMR based approach to segment rat vertebral structure affected by mixed osteolytic/osteoblastic destruction. Mixed vertebral metastases were developed via intracardiac injection of Ace-1 canine prostate cancer cells in three 4-week-old rnu/rnu rats. μCT imaging (for high resolution bone visualization), T1-weighted μMR imaging (for bone registration), and T2-weighted μMR imaging (for osteolytic tumor visualization) were conducted on one L1, three L2, and one L3 vertebrae (excised). One sample (L1-L3) was processed for undecalcified histology and stained with Goldner's trichome. The μCT and μMR images were registered using a 3D rigid registration algorithm with a mutual information metric. The vertebral microarchitecture was segmented from the μCT images using atlas-based demons deformable registration, l...Continue Reading

References

Jan 1, 1987·British Journal of Cancer·R E Coleman, R D Rubens
Nov 1, 1993·British Journal of Cancer·M E HillR D Rubens
Jul 21, 1999·Journal of Biomechanical Engineering·R E GuldbergG T Charras
Jan 14, 2000·Journal of Biomechanical Engineering·G L NieburT M Keaveny
Oct 24, 2000·The Orthopedic Clinics of North America·C P Beauchamp
Mar 27, 2004·Cancer Treatment and Research·Thomas J RosolLaurie K McCauley
May 7, 2004·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Yuan-Tsung Chen, Ming-Shi Wang
Aug 9, 2005·Clinical & Experimental Metastasis·Christine L ChafferElizabeth D Williams
Sep 6, 2005·Cancer Research·Christopher L HallEvan T Keller
Aug 23, 2006·Clinical Orthopaedics and Related Research·Shane BurchAlbert J M Yee
Jan 25, 2008·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Xuesong LuYazhu Chen
Oct 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lisa Wise-MilestoneCari M Whyne

❮ Previous
Next ❯

Citations

Mar 2, 2013·Radiology·Joseph E BurnsRonald M Summers
Dec 11, 2013·Medical Physics·Andrea FränzleRolf Bendl
May 7, 2014·Neurological Research·Cari M Whyne
Jan 28, 2014·Computer Methods in Biomechanics and Biomedical Engineering·Francisco SahliJorge Ramos-Grez
Oct 25, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ihor LuhachRobert J Gillies
Jan 24, 2019·Annals of Biomedical Engineering·Ayelet AtkinsCari M Whyne
Oct 20, 2020·Current Osteoporosis Reports·Cari M WhyneMichael Hardisty

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.