Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes

Clinical Ophthalmology
Noemi Burguera-GiménezGowtham Jonna

Abstract

To comprehensively evaluate visual function in eyes with geographic atrophy (GA) as compared to normal eyes. Sixty-three eyes from 63 patients ≥50 years old were recruited for this observational study; 31 were identified as normal macular health eyes and 32 with GA. Visual function was tested with best corrected visual acuity (BCVA), low luminance visual acuity (LLVA), low luminance deficit (LLD), reading speed, macular integrity microperimetry, fixation stability, and contrast sensitivity function (CSF). Anatomic function was evaluated with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF). Quality of life and vision were assessed with the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Visual function and quality of life are reduced in patients with GA. Moderate and strong correlations in the GA group were found between maximum reading speed (r = 0.787) (p˂0.01), CS spatial frequency 3 cpd (r = 0.441) (p˂0.05), CS spatial frequency 6 cpd (r = 0.524) (p˂0.01), fixation P1 (r = 0.379) (p˂0.05), macular sensitivity (r = 0.484) (p˂0.05) and atrophic area (r = -0.689) (p˂0.01), and the VFQ-25 composite score. The decreased visual function is reflected in a poor quality of...Continue Reading

References

Apr 1, 1997·Ophthalmology·D C Fletcher, R A Schuchard
Feb 24, 2000·The British Journal of Ophthalmology·M E McClureU Chakravarthy
Jul 27, 2001·Archives of Ophthalmology·C M MangioneUNKNOWN National Eye Institute Visual Function Questionnaire Field Test Investigators
Apr 25, 2003·International Ophthalmology Clinics·Arthur P Ginsburg
Nov 24, 2004·Investigative Ophthalmology & Visual Science·Steffen Schmitz-ValckenbergKlaus Rohrschneider
Jun 7, 2005·Visual Neuroscience·Sing-Hang Cheung, Gordon E Legge
Apr 12, 2006·Archives of Ophthalmology·Cristina A AugoodAstrid E Fletcher
Jun 13, 2006·BMC Ophthalmology·Christopher G OwenAstrid E Fletcher
Nov 23, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·N BansbackJ Brazier
Mar 28, 2008·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Robert P FingerHendrik P N Scholl
Aug 30, 2008·Progress in Retinal and Eye Research·Klaus RohrschneiderChristina Springer
Mar 4, 2009·Investigative Ophthalmology & Visual Science·Ivan J SuñerNeil M Bressler
Feb 5, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Noburu ShimaSophia V Reyes
Oct 12, 2010·Investigative Ophthalmology & Visual Science·Annal D MelethWai T Wong
May 11, 2011·Retina·Michael D CrosslandGordon E Legge
Oct 15, 2013·Ophthalmology·Gabriëlle H S BuitendijkCaroline C W Klaver
Dec 3, 2013·Progress in Retinal and Eye Research·Nicole T M SaksensCarel B Hoyng
Apr 29, 2016·JAMA Ophthalmology·Farzana ChoudhuryUNKNOWN Los Angeles Latino Eye Study Group
Nov 29, 2016·Investigative Ophthalmology & Visual Science·Miriam KimelNeil M Bressler
Jan 12, 2017·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Steffen Schmitz-Valckenberg
Apr 8, 2017·American Journal of Ophthalmology·Ramzi Gilbert SayeghUrsula Schmidt-Erfurth
Apr 10, 2017·Ophthalmology and Therapy·Riccardo SacconiGiuseppe Querques
May 23, 2017·F1000Research·Francesco BandelloGiuseppe Querques
May 26, 2017·International Journal of Retina and Vitreous·Juan Abel Ramírez EstudilloBenito Celis Suazo
Nov 8, 2017·Ophthalmology·Monika FleckensteinDaniela Ferrara
Feb 28, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Deanna J TaylorDavid P Crabb

❮ Previous
Next ❯

Citations

Jun 6, 2021·Ophthalmology and Therapy·Dolores CaswellJill Carlton

❮ Previous
Next ❯

Software Mentioned

Spectralis
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.