Multimodal Imaging in Neurofibromatosis Type 1-associated Nerve Sheath Tumors

RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
J SalamonThorsten Derlin

Abstract

Neurofibromatosis type 1 (NF1) is a neurogenetic disorder. Individuals with NF1 may develop a variety of benign and malignant tumors of which peripheral nerve sheath tumors represent the most frequent entity. Plexiform neurofibromas may demonstrate a locally destructive growth pattern, may cause severe symptoms and may undergo malignant transformation into malignant peripheral nerve sheath tumors (MPNSTs). Whole-body magnetic resonance imaging (MRI) represents the reference standard for detection of soft tissue tumors in NF1. It allows for identification of individuals with plexiform neurofibromas, for assessment of local tumor extent, and for evaluation of whole-body tumor burden on T2-weighted imaging. Multiparametric MRI may provide a comprehensive characterization of different tissue properties of peripheral nerve sheath tumors, and may identify parameters associated with malignant transformation. Due to the absence of any radiation exposure, whole-body MRI may be used for serial follow-up of individuals with plexiform neurofibromas. (18)F-fluorodeoxyglucose positron-emission-tomography (FDG PET/CT) allows a highly sensitive and specific detection of MPNST, and should be used in case of potential malignant transformation of...Continue Reading

Citations

Feb 16, 2017·AJR. American Journal of Roentgenology·Mark C LiszewskiEdward Y Lee
Apr 5, 2016·Journal of Magnetic Resonance Imaging : JMRI·Joseph T DavisGary R Schooler
Jan 27, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ravi V GottumukkalaMary-Louise C Greer
Jun 21, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Natalie WinterAlexander Grimm
Feb 19, 2017·Human Genetics·Hildegard Kehrer-SawatzkiDavid N Cooper
Jun 9, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Julian ZipfelMartin U Schuhmann
Dec 23, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charles TruilletMichael J Evans
Dec 4, 2020·World Journal of Clinical Cases·Hai-Ying ZhouHui Lu
Sep 5, 2020·Surgical Oncology Clinics of North America·Nathan W MeskoDaniel P Raymond

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.