Multimodal imaging to study the morphochemistry of basal cell carcinoma

Journal of Biophotonics
Nadine VoglerJürgen Popp

Abstract

Basal cell carcinoma is the most abundant malignant neoplasm in humans, the pathology of which is characterized by an abnormal proliferation of basal cells. Basal cell carcinoma can show a variety of different morphologies, which are based on different cellular biology. Furthermore, the carcinoma often grows invisibly to the eye imbedded in the surrounding skin. Therefore, in some cases its clinical detection is challenging. Thus, our work aims at establishing an unsupervised tissue classification method based on multimodal imaging and the application of chemometrics to discriminate basal cell carcinoma from non-diseased tissue. A case study applying multimodal imaging to ex-vivo sections of basal cell carcinoma is presented. In doing so, we apply a combination of various linear and non-linear imaging modalities, i.e. fluorescence, Raman and second-harmonic generation microscopy, to study the morphochemistry of basal cell carcinoma. The joint information content obtained by such multimodal approach in studying various aspects of the malignant tissue alterations associated with basal cell carcinoma is discussed.

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Citations

Mar 9, 2012·Analytical and Bioanalytical Chemistry·Katharina HartmannJürgen Popp
May 9, 2012·Journal of Biomedical Optics·Christoph KrafftJürgen Popp
Oct 23, 2012·Journal of Biomedical Optics·Zhengbin XuYoung L Kim
May 13, 2014·Digestive Diseases and Sciences·Riccardo Cicchi
Mar 3, 2011·Journal of Biomedical Optics·Tobias MeyerJürgen Popp
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Feb 18, 2015·Clinical Neurology and Neurosurgery·Bernd F M RomeikeJürgen Popp
Sep 15, 2016·International Journal of Molecular Sciences·Elen TolstikJürgen Popp
Nov 6, 2015·The Analyst·Lauren A AustinConor L Evans
Apr 16, 2015·Expert Review of Molecular Diagnostics·Katharina EberhardtJürgen Popp
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Jan 11, 2012·Journal of Biophotonics·Tong PengPeng Xi
Oct 3, 2013·Applied Optics·Anna MedyukhinaJürgen Popp
Jul 20, 2012·Journal of Biophotonics·Anna MedyukhinaJürgen Popp
Jul 7, 2018·Journal of Healthcare Engineering·Sishan CuiShuhua Yue
May 27, 2015·Experimental Dermatology·Johannes SchleusenerMartina C Meinke

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