Multimodal iron oxide (Fe3O4)-saturated lactoferrin nanocapsules as nanotheranostics for real-time imaging and breast cancer therapy of claudin-low, triple-negative (ER(-)/PR(-)/HER2(-))

Nanomedicine
Jagat R KanwarRupinder K Kanwar

Abstract

To unravel the multimodal nanotheranostic ability of Fe3O4-saturated bovine lactoferrin nanocapsules (FebLf NCs) in claudin-low, triple-negative breast cancer model. Xenograft study was performed to examine biocompatibility, antitumor efficacy and multimodal nanotheranostic action in combination with near-infrared live mice imaging. FebLf NCs exhibited a size range of 80 nm ± 5 nm with observed superparamagnetism. FebLf NCs successfully internalized into breast cancer cells through receptor-mediated endocytosis and induced apoptosis through the downregulation of inhibitor of apoptosis survivin and livin proteins. Investigations revealed a remarkable biocompatibility, anticancer efficacy of the FebLf NCs. Near-infrared imaging observations confirmed selective localization of multimodal FebLf NCs at the tumor site and lead to time-dependent reduction of tumor growth. FebLf NCs can be safe, biocompatible nanotheranostic approach for real-time imaging and monitoring the effect of drugs in real time and have potentials in future clinical trials.

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Citations

Apr 3, 2020·Journal of Biomolecular Structure & Dynamics·Masoumeh MehrabiAnwarul Hasan
Jan 19, 2018·Oncology Letters·Yu WangZhitu Zhu
May 15, 2018·Frontiers in Pharmacology·Yi GouGaoxing Su
Dec 31, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Md Sarwar ZahanMd Jamal Uddin

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Methods Mentioned

BETA
Scanning electron microscopy
Dynamic light scattering
X-ray
confocal microscopy
PCR
Fluorescence
xenograft
fluorescence imaging
electrophoresis

Software Mentioned

CyQuant
Image J

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