Multimodal Magnetic Resonance Imaging in Alzheimer's Disease Patients at Prodromal Stage

Journal of Alzheimer's Disease : JAD
Pierre EustachePatrice Peran

Abstract

One objective of modern neuroimaging is to identify markers that can aid in diagnosis, monitor disease progression, and impact long-term drug analysis. In this study, physiopathological modifications in seven subcortical structures of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD) were characterized by simultaneously measuring quantitative magnetic resonance parameters that are sensitive to complementary tissue characteristics (e.g., volume atrophy, shape changes, microstructural damage, and iron deposition). Fourteen MCI patients and fourteen matched, healthy subjects underwent 3T-magnetic resonance imaging with whole-brain, T1-weighted, T2*-weighted, and diffusion-tensor imaging scans. Volume, shape, mean R2*, mean diffusivity (MD), and mean fractional anisotropy (FA) in the thalamus, hippocampus, putamen, amygdala, caudate nucleus, pallidum, and accumbens were compared between MCI patients and healthy subjects. Comparisons were then performed using voxel-based analyses of R2*, MD, FA maps, and voxel-based morphometry to determine which subregions showed the greatest difference for each parameter. With respect to the micro- and macro-structural patterns of damage, our results suggest that differ...Continue Reading

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Citations

Apr 9, 2016·Molecular Neurobiology·Zi-Xuan WangUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 24, 2016·Acta Neuropsychiatrica·Antoine YrondiChristophe Arbus
Jan 12, 2019·British Journal of Pharmacology·Francis J HermanGiulio M Pasinetti
Mar 3, 2020·Psychological Medicine·Manuel J CuestaVictor Peralta
Mar 3, 2020·Journal of Medical Imaging·Saraswathi SubramanianUNKNOWN for Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Feb 13, 2020·Current Opinion in Neurology·Germain Arribarat, Patrice Péran
Feb 25, 2018·Journal of Prosthodontic Research·Takuya KobayashiHisatomo Kondo
Aug 28, 2020·Frontiers in Aging Neuroscience·Mingyue WanGuohua Zheng
Aug 29, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Milenna T van DijkArdesheer Talati
Dec 29, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Magdalena MroczekWadid Sirry

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Methods Mentioned

BETA
ELISA

Software Mentioned

FIRST
SIENAX
VBM
FSL
FMRIB Diffusion Toolbox – FSLv5
FIRST FMRIB Integrated Registration and Segmentation Tool )
MATLAB
FSL Randomise script
FMRIB Software Library ( FSL

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