Multimodal MR examination in acute ischemic stroke

Neuroradiology
D M MezzapesaF Federico

Abstract

In recent years, combined diffusion-weighted imaging (DWI) with perfusion imaging (PI) has become an important investigational tool in the acute phase of ischemic stroke, as it may differentiate reversible from irreversible brain tissue damage. We consecutively examined 20 subjects within 12 h of stroke onset using a multiparametric magnetic resonance (MR) examination consisting of DWI, mean transit time (MTT) as PI parameter, and MR angiography (MRA). T2-weighted and fluid-attenuated inversion recovery (FLAIR) on day 7 were also acquired in order to obtain final infarct volume. The following MR parameters were considered: volumetric measures of lesion growth and MTT abnormalities, quantification of regional apparent diffusion coefficient (ADC) and visual inspection of MRA findings. Our results showed: (1) an acute DWI lesion was not predictive of lesion growth and the DWI abnormality did not represent the irreversibly infarcted tissue; (2) ADC values in the ischemic penumbra could not predict tissue at risk; (3) the DWI-PI mismatch did not predict lesion growth, and the PI abnormality overestimated the amount of tissue at risk; and (4) patients with proximal middle cerebral artery occlusion had greater initial and final infarc...Continue Reading

References

May 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M E MoseleyP R Weinstein
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
May 1, 1988·Stroke; a Journal of Cerebral Circulation·J C van SwietenJ van Gijn
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·T Neumann-HaefelinH J Freund
Jun 3, 2000·Stroke; a Journal of Cerebral Circulation·T Neumann-HaefelinH J Freund
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·S L Keir, J M Wardlaw
May 3, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J FiehlerJ Röther
Nov 3, 2001·Stroke; a Journal of Cerebral Circulation·C OppenheimG Cosnard
Oct 31, 2002·Cerebrovascular Diseases·Jens FiehlerJoachim Röther
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Marc Fisher, Thomas G Brott
May 10, 2003·Stroke; a Journal of Cerebral Circulation·Ludy C ShihChelsea S Kidwell
Nov 6, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marc HermierJean-Claude Froment
Jan 24, 2004·Stroke; a Journal of Cerebral Circulation·Jens FiehlerJoachim Röther
Apr 20, 2004·Current Opinion in Neurology·Joseph V GuadagnoJean-Claude Baron
Jul 23, 2004·Journal of Magnetic Resonance Imaging : JMRI·Afra RitzlRüdiger J Seitz
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellJeffrey L Saver

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Citations

Oct 24, 2007·Neuroradiology·Christina PlankMajda M Thurnher
Dec 8, 2009·Neuroradiology·Stephan P KloskaJochen B Fiebach
Jun 30, 2009·European Journal of Radiology·Korcan Aysun Gonen, Mehmet Masum Simsek
Oct 17, 2008·Radiologic Clinics of North America·John B Weigele, Robert W Hurst
Nov 12, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kimmo T JokivarsiOlli H J Gröhn

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