Multimodal nanoparticles that provide immunomodulation and intracellular drug delivery for infectious diseases

Nanomedicine : Nanotechnology, Biology, and Medicine
Admire DubeGene D Morse

Abstract

Infectious diseases are a worldwide health concern. For some infections, a common feature is the intracellular residence of the pathogen and evasion of the host immune response. In the case of tuberculosis (TB), Mycobacterium tuberculosis evades clearance within macrophages through suppression of intracellular reactive oxygen and nitrogen species (ROS/RNS) and pro-inflammatory cytokines. We propose new nanoparticle designs for infectious diseases, functionalized with ligands able to modulate the cellular immune response and concurrently deliver drug. We have designed 1,3-β-glucan functionalized chitosan shell, poly(lactide)co-glycolide core nanoparticles to stimulate ROS/RNS, pro-inflammatory cytokine secretion, and delivery of rifampicin inside human alveolar like macrophages (ALM). Nanoparticles significantly enhanced ALM secretion of IL-12p70 (2.9-fold), TNF-α (16-fold) and INF-γ (23-fold) compared to controls over 24h, and doubled ROS/RNS generation over 6h. Nanoparticles could deliver 4-fold greater rifampicin into ALM compared to rifampicin solution. These results provide proof-of-concept of multimodal nanoparticles and support their further development. In this paper, a new nanoparticle design is proposed to address hard...Continue Reading

References

Mar 28, 1998·American Journal of Respiratory and Critical Care Medicine·N W Schluger, W N Rom
Sep 7, 2001·Nature·G D Brown, S Gordon
May 3, 2002·FEMS Immunology and Medical Microbiology·Geir Hetland, Per Sandven
Jan 24, 2004·Biomaterials·M N V Ravi KumarC M Lehr
Feb 22, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·David J Kusner
Aug 29, 2007·Antimicrobial Agents and Chemotherapy·Tawanda GumboGeorge L Drusano
Nov 14, 2008·Experimental Lung Research·Aaron R WinklerCara M M Williams
Jan 24, 2009·Immunological Reviews·Andrea M Cooper, Shabaana A Khader
Jul 15, 2009·Immunological Reviews·Helen S GoodridgeDavid M Underhill
Feb 1, 2009·Expert Review of Respiratory Medicine·Rajko ReljicMauricio A Arias
Jan 15, 2011·Clinical & Developmental Immunology·Suhail Ahmad
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jacques GrossetWilliam R Bishai

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Citations

Jan 23, 2016·Chemical Reviews·Guanying ChenParas N Prasad
Dec 22, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marianna FoldvariAmirreza Rafiee
Sep 4, 2015·Angewandte Chemie·Peter LeidingerClaus Feldmann
Jun 7, 2015·Biotechnology Advances·Ana Sara CordeiroMaría de la Fuente
May 6, 2015·Colloids and Surfaces. B, Biointerfaces·Muzamil Yaqub WantFarhat Afrin
May 18, 2016·Journal of Drug Delivery·Faithful Makita-ChingombeCharles C Maponga
Mar 1, 2015·Pharmaceutical Research·Matshawandile TukululaAdmire Dube
Aug 15, 2018·Journal of Drug Targeting·Sweet NaskarSuraj Sharma
Nov 20, 2016·Angewandte Chemie·Silke Wolf, Claus Feldmann
Jan 27, 2017·Future Virology·Hilliard L KutscherJessica L Reynolds
May 26, 2018·Nanotechnology·Ivana BoriševAleksandar Djordjevic
Mar 25, 2017·Nanomaterials·Marta Álvarez-PainoMarta Fernández-García
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Brenda KischkelCarlos P Taborda
Dec 15, 2019·Nanomaterials·Daniela Plachá, Josef Jampilek
Dec 8, 2020·Macromolecular Bioscience·Jeongyun HeoJessica L Reynolds
Feb 14, 2021·Polymers·Clément ToullecChristine Jérôme
Apr 17, 2021·Scientific Reports·Shivang K DesaiSmritilekha Bera
Apr 10, 2019·Molecular Pharmaceutics·Edna SoaresOlga Borges
Mar 7, 2020·Chemical Research in Toxicology·Mariana ColaçoOlga Borges

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