DOI: 10.1101/19013193Feb 5, 2020Paper

Multimodal neuroimaging and suicidality in a US population-based sample of school-aged children

MedRxiv : the Preprint Server for Health Sciences
Pablo Vidal-RibasA. Stringaris

Abstract

Importance: Suicide deaths and suicidality are considered a public health emergency, yet their brain underpinnings remain elusive. Objective: To examine individual, environmental, and clinical characteristics, as well as multimodal brain imaging correlates of suicidality in a US population-based sample of school-aged children. Design: Cross-sectional analysis of the first wave of data from the Adolescent Brain Cognitive Development study Setting: Multicenter population-based study Participants: Children aged 9-10 years from unreferred, community samples with suicidality data available (n=7,994). Following quality control, we examined structural magnetic resonance imaging (sMRI) (n=6,238), resting state functional MRI (rs-fMRI) (n=4,134), and task-based fMRI (range n=4,075 to 4,608). Exposure: Lifetime suicidality, defined as suicidal ideation, plans and attempts reported by children or/and caregivers. Main Outcomes and Measures: Multimodal neuroimaging analyses examined differences with Welch t-test and Equivalence Tests, with observed effect sizes (ES, Cohen d) and their 90% confidence interval (CI) < |0.15|. Predictive values were examined using the area under precision-recall curves (AUPRC). Measures included, cortical volum...Continue Reading

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Palliative & Supportive Care
Simon Wein
Journal of the American Academy of Child and Adolescent Psychiatry
Charles H Zeanah, Mary Margaret Gleason
The American Journal of Psychiatry
H L White
Journal of Consulting and Clinical Psychology
C V Leonard
MMW Fortschritte der Medizin
K Lieb
© 2021 Meta ULC. All rights reserved