DOI: 10.1101/19013193Feb 5, 2020Paper

Multimodal neuroimaging and suicidality in a US population-based sample of school-aged children

MedRxiv : the Preprint Server for Health Sciences
Pablo Vidal-RibasA. Stringaris


Importance: Suicide deaths and suicidality are considered a public health emergency, yet their brain underpinnings remain elusive. Objective: To examine individual, environmental, and clinical characteristics, as well as multimodal brain imaging correlates of suicidality in a US population-based sample of school-aged children. Design: Cross-sectional analysis of the first wave of data from the Adolescent Brain Cognitive Development study Setting: Multicenter population-based study Participants: Children aged 9-10 years from unreferred, community samples with suicidality data available (n=7,994). Following quality control, we examined structural magnetic resonance imaging (sMRI) (n=6,238), resting state functional MRI (rs-fMRI) (n=4,134), and task-based fMRI (range n=4,075 to 4,608). Exposure: Lifetime suicidality, defined as suicidal ideation, plans and attempts reported by children or/and caregivers. Main Outcomes and Measures: Multimodal neuroimaging analyses examined differences with Welch t-test and Equivalence Tests, with observed effect sizes (ES, Cohen d) and their 90% confidence interval (CI) < |0.15|. Predictive values were examined using the area under precision-recall curves (AUPRC). Measures included, cortical volum...Continue Reading

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