Multimodal safety assessment of measles-mumps-rubella vaccination after pediatric liver transplantation

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Laure F PittetKlara M Posfay-Barbe

Abstract

Live-attenuated vaccines are currently contraindicated in solid-organ transplant recipients. However, the risk of vaccine-preventable infections is lifelong, and can be particularly severe after transplantation. In this prospective interventional national cohort study, 44 pediatric liver transplant recipients with measles IgG antibodies <150 IU/L (below seroprotection threshold) received measles-mumps-rubella vaccine (MMR) at a median of 6.3 years posttransplantation (interquartile range, 4.0 to 10.9). A maximum of two additional doses were administered in nonresponders or when seroprotection was lost. Vaccine responses occurred in 98% (95% confidence interval [CI], 88-100) of patients. Seroprotection at 1-, 2-, and 3-year follow-up reached 62% (95% CI, 45-78), 86% (95% CI, 70-95), and 89% (95% CI, 67-99), respectively. All patients responded appropriately to the booster dose(s). Vaccinations were well tolerated and no serious adverse event attributable to vaccination was identified during the 8-week follow-up period (or later), using a multimodal approach including standardized telephone interviews, diarized side effect reporting, and monitoring of vaccinal virus shedding. We conclude that live attenuated MMR vaccine can be ad...Continue Reading

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Citations

May 12, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paolo Antonio Grossi
Sep 26, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Amy G FeldmanDeepali Kumar
Oct 28, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Zeynep Idil SeckinClaudia R Libertin
Dec 4, 2019·Current Opinion in Pediatrics·Katrina MillerTanvi Sharma
Oct 1, 2019·Current Opinion in Nephrology and Hypertension·Shilpa R Jain, Deepali Kumar
Sep 10, 2019·Pediatric Transplantation·Sneha SureshUpton D Allen
Dec 15, 2020·Pediatric Transplantation·Takanori FunakiIsao Miyairi
Feb 11, 2021·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Zeynep Idil SeckinLisa M Brumble
Jan 9, 2022·Clinical Transplantation·Justin K ChenInci Yildirim
Dec 31, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Alexander M NewmanWilliam J Muller

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