Multimodal strategies for resuscitating injured cells

Annals of the New York Academy of Sciences
Jayant AgarwalRaphael C Lee

Abstract

Our cells and tissues are challenged constantly by exposure to extreme conditions that cause acute and chronic stress. Wounding at the cellular level is a common event, and results from cell exposure to supra-physiologic forces, or is the consequence of action by reactive chemical agents. An individual cellular wound results from either the alteration of protein or DNA structure, or the disruption of molecular assemblies, the most important of which is the cell's membranes. Tissue healing at the macroscopic level is a complex and coordinated process involving many different cell types while, in contrast, the wounds of individual cells heal primarily via biomolecular interactions. Like tissue wound healing, cellular wound healing involves the upregulation or acceleration of processes that are constitutively expressed in routine physiologic repair of cellular structures In addition, recent advances have been made in the identification of pharmaceutical strategies to aid the cellular repair response. Many of these strategies offer promise for augmenting the already present cellular repair mechanisms.

References

Oct 1, 1992·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R A MounseyC Forrest
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C LeeR L Wollmann
Mar 1, 1990·Biochimica Et Biophysica Acta·K ArnoldW Herold
Jul 21, 1988·Journal of Theoretical Biology·D C GaylorR C Lee
Nov 1, 1995·Plastic and Reconstructive Surgery·J A JensenE D Gierson
Dec 1, 1995·Plastic and Reconstructive Surgery·M A CodnerF F Eaves
May 31, 1994·Annals of the New York Academy of Sciences·J T PadanilamM Toner
May 31, 1994·Annals of the New York Academy of Sciences·W Chen, R C Lee
May 31, 1994·Annals of the New York Academy of Sciences·T Y Tsong, C J Gross
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D DietrichM D Ginsberg
Nov 1, 1996·Burns : Journal of the International Society for Burn Injuries·R C Lee, R D Astumian
Apr 7, 1997·The Journal of Cell Biology·P L McNeil, R A Steinhardt
Jul 1, 1997·Plastic and Reconstructive Surgery·C M CarrollJ H Barker
May 20, 1998·The Journal of Surgical Research·F A MerchantM Toner
Dec 5, 2000·Molecular Biology of the Cell·T TogoR A Steinhardt
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J D MarksR C Lee
May 24, 2001·The Journal of Biological Chemistry·Z Livneh
Oct 26, 2001·The Journal of Surgical Research·H BaskaranF Berthiaume
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y YamamotoW C Dunlap
Dec 18, 2001·Journal of Neuroscience Research·R B Borgens, D Bohnert
Feb 28, 2002·Biophysical Journal·Stacey A MaskarinecKa Yee C Lee
May 16, 2003·Health Physics·G H AnnoJ R Mercier
Aug 9, 2003·Critical Care Medicine·Katsuya Miyake, Paul L McNeil
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Paul L McNeil, Richard A Steinhardt
Mar 27, 2004·FEMS Microbiology Letters·Fernando L PalhanoPatricia M B Fernandes
Mar 30, 2004·Journal of Neuroscience Research·Richard B BorgensRaphael C Lee

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Citations

Jan 20, 2010·Critical Care Medicine·John C Alverdy
Jun 2, 2012·Journal of Cardiovascular Pharmacology·Elizabeth B JunemanSteven Goldman
May 28, 2011·Plastic and Reconstructive Surgery·Miguel A MedinaWilliam G Austen
Jul 25, 2008·The Journal of Craniofacial Surgery·Neil D Dalal, Raphael C Lee
Oct 14, 2016·Nature·Martin P StewartKlavs F Jensen
Jul 3, 2018·Nanoscale·Shwathy RamesanLeslie Y Yeo
Aug 15, 2014·Biofabrication·Hemanth GudapatiDouglas B Chrisey
Mar 9, 2020·Cardiovascular Drugs and Therapy·Hani N SabbahMartin Emanuele
Oct 27, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Wenjia ZhangTimothy P Lodge
Jul 28, 2018·Chemical Reviews·Martin P StewartKlavs F Jensen

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