Multimodal transport and dispersion of organelles in narrow tubular cells

Physical Review. E
Saurabh S Mogre, Elena F Koslover

Abstract

Intracellular components explore the cytoplasm via active motor-driven transport in conjunction with passive diffusion. We model the motion of organelles in narrow tubular cells using analytical techniques and numerical simulations to study the efficiency of different transport modes in achieving various cellular objectives. Our model describes length and time scales over which each transport mode dominates organelle motion, along with various metrics to quantify exploration of intracellular space. For organelles that search for a specific target, we obtain the average capture time for given transport parameters and show that diffusion and active motion contribute to target capture in the biologically relevant regime. Because many organelles have been found to tether to microtubules when not engaged in active motion, we study the interplay between immobilization due to tethering and increased probability of active transport. We derive parameter-dependent conditions under which tethering enhances long-range transport and improves the target capture time. These results shed light on the optimization of intracellular transport machinery and provide experimentally testable predictions for the effects of transport regulation mechani...Continue Reading

References

Feb 1, 1997·Molecular and Cellular Biochemistry·I Singh
Jun 9, 2000·Annual Review of Neuroscience·L S Goldstein, Z Yang
Feb 20, 2003·The Journal of Biological Chemistry·Paul Targett-AdamsJohn McLauchlan
Jul 23, 2004·Current Biology : CB·Sonita R Chada, Peter J Hollenbeck
Feb 16, 2005·Nature Reviews. Neuroscience·Nobutaka Hirokawa, Reiko Takemura
Feb 23, 2005·Current Biology : CB·Nicholas A BrightJ Paul Luzio
Apr 27, 2005·Nature Reviews. Molecular Cell Biology·Daniel St Johnston
Dec 13, 2005·Molecular Biology of the Cell·Anne StraubeGero Steinberg
Feb 10, 2006·Molecular Biology of the Cell·Aaron D PillingWilliam M Saxton
Feb 14, 2006·Nature Cell Biology·Tara L Culver-HanlonStephen J King
Feb 21, 2006·Physical Review Letters·Stefan Klumpp, Reinhard Lipowsky
Jun 30, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diane T W ChangIan J Reynolds
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Comert KuralPaul R Selvin
Oct 20, 2007·Traffic·Rebecca L Frederick, Janet M Shaw
Jan 30, 2008·Current Opinion in Cell Biology·Jennifer L RossDavid M Warshaw
Jan 30, 2008·Biophysical Journal·Jennifer L RossYale E Goldman
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Melanie J I MüllerReinhard Lipowsky
Mar 21, 2008·Nature Reviews. Molecular Cell Biology·Maria Antonietta De Matteis, Alberto Luini
Dec 31, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Aviv KahanaRony Granek
Feb 3, 2009·Current Opinion in Cell Biology·Jeremy R Cooper, Linda Wordeman
Aug 8, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·L BrunoM A Despósito
Aug 25, 2009·Trends in Cell Biology·Clifford P BrangwynneDavid A Weitz
Nov 17, 2009·Structure·Harsha V MudrakolaBianxiao Cui
Apr 20, 2010·Current Biology : CB·Adam G HendricksErika L F Holzbaur
Jun 2, 2010·Biophysical Journal·Melanie J I MüllerReinhard Lipowsky
Feb 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Martin SchusterGero Steinberg
Aug 13, 2011·Molecular Biology of the Cell·Martin SchusterGero Steinberg
Aug 17, 2011·Biophysical Journal·Elena F KosloverAndrew J Spakowitz
Mar 6, 2012·Biophysical Journal·Stephen J Peter, Mohammad R K Mofrad
Nov 7, 2012·Current Opinion in Microbiology·Martin J EganSamara L Reck-Peterson
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Štefan BálintMelike Lakadamyali
Jun 12, 2013·Translational Neuroscience·Xin-An LiuSathyanarayanan V Puthanveettil
Jun 26, 2013·Cell·Vaishnavi AnanthanarayananIva M Tolić-Nørrelykke
Feb 6, 2014·PloS One·Debjyoti BandyopadhyayChristine K Payne
Mar 29, 2014·Scientific Reports·Wylie W Ahmed, Taher A Saif
Jun 19, 2014·Biophysical Journal·Matan MusselUri Nevo
Jun 24, 2014·Trends in Cell Biology·Meng-meng Fu, Erika L F Holzbaur
Aug 15, 2014·Nature Reviews. Molecular Cell Biology·William O Hancock
Jun 13, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·D CamposK Lindenberg
Aug 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Aljaž Godec, Ralf Metzler

❮ Previous
Next ❯

Citations

Jul 25, 2019·Physical Review. E·Bryan MaelfeytAjay Gopinathan
Jul 15, 2020·Physical Biology·Saurabh S MogreElena F Koslover
Feb 18, 2020·Biophysical Journal·Saurabh S MogreElena F Koslover
Jun 19, 2021·The European Physical Journal. E, Soft Matter·Zubenelgenubi C ScottElena F Koslover
Oct 24, 2021·Biophysical Journal·Saurabh S MogreElena F Koslover

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Astrid S de Wijn
Current Biology : CB
Adam G HendricksErika L F Holzbaur
© 2022 Meta ULC. All rights reserved