Multimodal treatment of calcific uraemic arteriolopathy (calciphylaxis): a case series

Clinical Kidney Journal
Domenico RussoCarmine Zoccali

Abstract

This is an incident series of five dialysis patients with late-diagnosed calcific uraemic arteriolophathy (CUA), severe uncontrolled hyperparathyroidism and infected skin ulcerations. A multimodal intervention was based on wound care, antibiotics, surgical debridement, sodium thiosulphate and cinacalcet and associated with regression of skin disease in four cases after varying treatment time periods ranging from 4 to 33 months. Multimodal treatment including sodium thiosulphate and cinacalcet was associated with very favourable local outcomes and survival. This series further confirms that the diagnosis of CUA is rarely made at the nodular, non-ulcerative phase of the disease. This series contributes to the build-up of case series reporting on the treatment of CUA, and will hopefully serve as a basis of well-conceived comparative effectiveness studies investigating the value of the combined interventions applied so far in this severe condition.

References

May 25, 2002·Kidney International·Adrian Fine, James Zacharias
Apr 11, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nestor VelascoIan G MacKay
Nov 17, 2006·The British Journal of Dermatology·A SharmaR Rustom
Feb 21, 2007·Archives of Dermatology·Maria R RobinsonNeil J Korman
Jan 8, 2008·Acta Dermato-venereologica·Valérie PallureOlivier Dereure
Jun 28, 2008·La Revue de médecine interne·S PreyJ-M Bonnetblanc
Jul 26, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Colette B Raymond, Lori D Wazny
Oct 1, 2008·The International Journal of Artificial Organs·I KyritsisB Agroyannis
Oct 23, 2008·Current Opinion in Nephrology and Hypertension·Natasha M Rogers, Patrick Toby H Coates
Jan 6, 2011·Journal of Postgraduate Medicine·E Gonzalez-ParraA Ortiz
Apr 12, 2011·Journal of Cutaneous Medicine and Surgery·Despoina KakagiaVassilios Vargemezis
Aug 30, 2011·American Journal of Surgery·Zain Khalpey, Stefan G Tullius
Aug 30, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Corisande BaldwinAdeera Levin
Sep 3, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Nina ScolaAlexander Kreuter
Jan 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emanuel ZittKarl Lhotta
Mar 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Sagar U NigwekarEduardo Lacson
Sep 13, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Davide BolignanoCarmine Zoccali
Nov 20, 2013·Kidney & Blood Pressure Research·Hermann SalmhoferChristoph Schmaderer
Jan 30, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vincent M BrandenburgMarkus Ketteler
Feb 15, 2014·Journal of Medical Case Reports·Hui-Tsung YehYao-Min Hung
Jul 19, 2014·BMJ Case Reports·Lisa BorgesIsabel Cássio
Dec 17, 2014·Seminars in Nephrology·Vincent M BrandenburgSandro Mazzaferro
Feb 25, 2015·International Journal of Nephrology and Renovascular Disease·Ramón Alberto Tamayo-Isla, Mauro Cuba de la Cruz
Apr 19, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Jürgen FloegePatrick S Parfrey
Apr 29, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Georg SchlieperJürgen Floege
May 12, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sagar U NigwekarRavi I Thadhani

❮ Previous
Next ❯

Citations

Apr 5, 2017·Current Opinion in Nephrology and Hypertension·Sagar U Nigwekar
Jan 23, 2019·The Australasian Journal of Dermatology·Jacqueline Deen, Helmut Schaider
Jan 5, 2017·Journal of the American Society of Nephrology : JASN·Sagar U NigwekarRajeev Malhotra
May 23, 2019·JAMA Dermatology·Lisa Mask-BullAlun Wang
Feb 20, 2018·Dermatopathology·Eduardo De FlammineisDaniela Kroshinsky
Apr 23, 2017·BMC Nephrology·Margret PateckiWilfried Gwinner
Oct 6, 2018·Clinical Kidney Journal·Claire HarrisMyriam Farah

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
dissect

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Current Opinion in Nephrology and Hypertension
Natasha M Rogers, Patrick Toby H Coates
Nefrología : publicación oficial de la Sociedad Española Nefrologia
José V TorregrosaJosep M Campistol
Nefrología : publicación oficial de la Sociedad Española Nefrologia
L Salanova VillanuevaP Sanz
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Karen M DwyerBrendan F Murphy
© 2022 Meta ULC. All rights reserved