Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know

Insights Into Imaging
Francesco AlessandrinoAngela A Giardino

Abstract

Indolent B cell lymphomas are a group of lymphoid malignancies characterized by their potential to undergo histologic transformation to aggressive lymphomas. While different subtypes of indolent B cell lymphomas demonstrate specific clinical and imaging features, histologic transformation can be suspected on cross-sectional imaging when disproportionate lymph node enlargement or new focal lesions in extranodal organs are seen. On PET/CT, transformed indolent lymphoma may show new or increased nodal FDG avidity or new FDG-avid lesions in different organs. In this article, we will (1) review the imaging features of different subtypes of indolent B cell lymphomas, (2) discuss the imaging features of histologic transformation, and (3) propose a diagnostic algorithm for transformed indolent lymphoma. The purpose of this review is to familiarize radiologists with the spectrum of clinical and imaging features of indolent B cell lymphomas and to define the role of imaging in raising concern for transformation and in guiding biopsy for confirmation.

References

Feb 6, 1988·Lancet·A G StansfeldO Mioduszewska
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J O Armitage, D D Weisenburger
Apr 25, 2001·Histopathology·H K Müller-HermelinkG Ott
Feb 8, 2005·Best Practice & Research. Clinical Haematology·Ama Z S Rohatiner, T Andrew Lister
Nov 24, 2005·Hematology·Catherine Thieblemont
Aug 31, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E GinéA López-Guillermo
Feb 22, 2007·Blood·John G Gribben
Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ana MuntañolaEmili Montserrat
May 9, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silvia MontotoT Andrew Lister
Jan 2, 2008·Haematologica·Catherine AnsquerThierry Lamy
Apr 17, 2008·Neurology·J DrappatzS Kesari
Jul 16, 2008·Radiologic Clinics of North America·Matthew J Matasar, Andrew D Zelenetz
Aug 22, 2008·AJR. American Journal of Roentgenology·Olga MaksimovicMarius Horger
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Theresa H M KeeganChristina A Clarke
Jan 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mubarak Al-MansourKerry J Savage
Apr 13, 2010·Clinical Radiology·D HayashiA Guermazi
Jul 24, 2010·AJR. American Journal of Roentgenology·Daichi HayashiAli Guermazi
Dec 2, 2010·Journal of Cancer Research and Therapeutics·Noushif Medappil, R Reghukumar
Jan 12, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Angela A GiardinoAnn Lacasce
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silvia Montoto, Jude Fitzgibbon
Jun 4, 2011·Clinical Nuclear Medicine·Yen-Kung ChenChia-Hung Kao
Jun 11, 2011·Best Practice & Research. Clinical Haematology·M S Hofman, R J Hicks
Jun 18, 2011·American Journal of Hematology·Ranjit BanwaitIrene M Ghobrial
Nov 19, 2011·The British Journal of Radiology·S S SabooJ P Jagannathan
Jun 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ronald C WalkerTwyla Bartel
Jul 28, 2012·Lancet·Kate R ShanklandBarry W Hancock
Jan 15, 2014·British Journal of Haematology·Mohammad O KhalilGraça M Dores
Jun 14, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Andrew D ZelenetzHema Sundar
Jun 27, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Jean François GrellierPauline Brice
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sally F BarringtonBruce D Cheson
Dec 17, 2014·Blood·Carla CasuloJonathan W Friedberg
Dec 21, 2014·Blood·Stephen D SmithKieron Dunleavy
May 24, 2015·Blood·Steven P Treon
Jul 24, 2015·Radiology·Sarah A JohnsonJürgen Rademaker

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Citations

Nov 30, 2019·Insights Into Imaging·Francesco AlessandrinoNikhil H Ramaiya
Jun 21, 2021·European Journal of Radiology·Lucia ZanoniStefano Fanti
Dec 18, 2021·Science Progress·Petr HoffmannPetr Dvorak

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Methods Mentioned

BETA
biopsy
biopsies

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