Multimodality locoregional treatment strategies for bridging HCC patients before liver transplantation

European Surgery : ACA : Acta Chirurgica Austriaca
Georg P GyöriGabriela A Berlakovich

Abstract

It is current practice that patients with hepatocellular carcinoma (HCC) listed for liver transplantation should receive locoregional treatment if the suspected waiting time for transplantation is longer than 6 months, even in the absence of prospective randomized data. Aim of this study was the comparison of single versus multimodality locoregional treatment strategies on outcomes after liver transplantation. This is a retrospective analysis of 150 HCC patients listed for liver transplantation at our center between 2004 and 2011. Outcomes were analyzed according to modified Response Evaluation Criteria in Solid Tumors (mRECIST) in relation to intention-to-treat and overall survival after liver transplantation. Overall, 92 patients (63%) were transplanted in this cohort. The intention-to-treat 1‑, 3‑, 5‑year waiting list survival was 80, 59, and 50% respectively. In RFA-(radiofrequency ablative) and TACE-(transarterial chemoembolisation)-based regimens, rates of transplanted patients were comparable (69 vs. 58%, p = ns). No difference was seen in overall survival after liver transplantation when comparing TACE- and RFA-based regimens. Patients receiving multimodality locoregional therapy had lower overall survival after transpl...Continue Reading

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Citations

Aug 29, 2020·Journal of Gastrointestinal Cancer·Sami Akbulut, Cemalettin Koc
Jun 8, 2018·European Surgery : ACA : Acta Chirurgica Austriaca·D PutzerR J Bale
Jun 8, 2018·European Surgery : ACA : Acta Chirurgica Austriaca·Eva BraunwarthFlorian Primavesi

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Software Mentioned

SPSS Statistics
mRECIST
SPSS

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