Multimodality therapy of an acquired factor V inhibitor

American Journal of Hematology
Y X FuM A Blinder

Abstract

Acquired inhibitors of factor V are rare causes of clinical bleeding, whose severity ranges from mild to life-threatening. Optimal treatment of patients with factor V inhibitors is uncertain. We report on our successful treatment approach in a patient with spontaneous, life-threatening intracranial bleeding caused by a factor V inhibitor. The patient deteriorated after initial treatment with fresh-frozen plasma and platelet transfusions. He was subsequently treated with a combination of plasma exchange and chemotherapy, which led to complete recovery. Our experience suggests that plasma exchange may be life-saving in cases of severe bleeding caused by factor V inhibitors. The use of plasmapheresis in conjunction with chemotherapy is an efficacious and well-tolerated treatment and should be considered in patients with factor V inhibitors.

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Citations

Oct 22, 2010·Internal Medicine·Tsukasa NozuToshikatsu Okumura
Feb 4, 2011·The American Journal of the Medical Sciences·Ravi K BobbaCarl E Freter
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Jan 20, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giuseppe LippiMassimo Franchini
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Jan 15, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Joseph BennettFred V Plapp

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