Multimodality treatment in the control of deep musculoaponeurotic fibromatosis

The British Journal of Surgery
A I SkeneJ Meirion Thomas

Abstract

Deep musculoaponeurotic fibromatoses are rare soft tissue neoplasms with a propensity for local recurrence. A retrospective analysis was carried out of the factors contributing to local disease control in 75 patients treated between 1963 and 1993. Multivariate analysis identified the type of surgical excision (P < 0.001) and involvement of pathological resection margins (P < 0.02) as significant factors contributing to local recurrence. After a median follow up of 47 months (range 24 months to 29 years) 31 (49 per cent) of the 63 patients who had an 'adequate' surgical resection developed local recurrence. The median time before development of local recurrence was 83.4 (range 8-129) months in patients with clear pathological resection margins. This was significantly shortened to 13.1 (range 2-35) months in those with positive margins (P < 0.001). Adequate surgical extirpation is the most important determinant in local disease control. Treatment of local recurrence ranged from observation during periods of disease stabilization to multimodality treatment for aggressive disease.

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Citations

Dec 17, 2005·AJR. American Journal of Roentgenology·Justin C LeeEleanor Moskovic
Mar 24, 2009·Journal of Pediatric Surgery·Navanjun S GrewalPhilip K Frykman
Dec 3, 2008·European Journal of Radiology·G CastellazziS Bonvalot
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GronchiJ Rosai
Nov 14, 2014·The American Journal of Surgical Pathology·Justin M M Cates, Thomas P Stricker
Feb 15, 2013·Expert Review of Anticancer Therapy·Andrea FerrariGianni Bisogno
Oct 27, 2004·The British Journal of Surgery·S R PhillipsJ M Thomas

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