Multimorbidity, age-related comorbidities and mortality: association of activation, senescence and inflammation markers in HIV adults

AIDS
Pierre DuffauLinda Wittkop

Abstract

The widespread introduction of combination antiretroviral therapy (cART) has increased survival of HIV-infected patients. However, the prevalence of age-related comorbidities remains higher than that of the general population, suggesting that individuals with HIV suffer from accelerated aging. Immune activation, senescence and inflammation could play an important role in this process. The CIADIS (Chronic Immune Activation anD Senescence) sub-study analyzed biomarkers of activation, differentiation and senescence of T cells in a cellular-CIADIS-weighted score, whereas biomarkers of inflammation were analyzed in a soluble CIADIS-weighted score using principal component analysis. Adjusted logistic regression and Cox proportional hazard models were used to determine the association between CIADIS-weighted scores and the presence of multimorbidity, time to occurrence of the first new age-related comorbidity and time to death, over a 3-year follow-up period. Of 828 patients with an undetectable viral load, a higher cellular-CIADIS-weighted score and higher TNFRI levels were independently associated with the presence of multimorbidity (OR 1.3; 95% CI 1.0-1.6; P = 0.02), but the soluble CIADIS-weighted score was not (OR = 1.1; 95% CI 0...Continue Reading

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Apr 19, 2020·AIDS and Behavior·Stephanie ShiauPerry N Halkitis
Oct 14, 2020·Sexually Transmitted Infections·Massimo GiulianiAlessandra Latini
Feb 5, 2021·Expert Review of Clinical Immunology·Paolo MaggiGiuseppe Vittorio Socio
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