Multimorbidity in risk stratification tools to predict negative outcomes in adult population

European Journal of Internal Medicine
Edurne Alonso-MoránGiuseppe Tonnara

Abstract

Risk stratification tools were developed to assess risk of negative health outcomes. These tools assess a variety of variables and clinical factors and they can be used to identify targets of potential interventions and to develop care plans. The role of multimorbidity in these tools has never been assessed. To summarize validated risk stratification tools for predicting negative outcomes, with a specific focus on multimorbidity. MEDLINE, Cochrane Central Register of Controlled Trials and PubMed database were interrogated for studies concerning risk prediction models in medical populations. Review was conducted to identify prediction models tested with patients in both derivation and validation cohorts. A qualitative synthesis was performed focusing particularly on how multimorbidity is assessed by each algorithm and how much this weighs in the ability of discrimination. Of 3674 citations reviewed, 36 articles met criteria. Of these, 29 had as outcome hospital admission/readmission. The most common multimorbidity measure employed in the models was the Charlson Comorbidity Index (12 articles). C-statistics ranged between 0.5 and 0.85 in predicting hospital admission/ readmission. The highest c-statistics was 0.83 in models with ...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Apr 20, 2002·Epidemiology·Kathleen G PutnamK Arnold Chan
Aug 31, 2004·Health Services Research·Eric A ColemanAndrew M Kramer
Nov 6, 2007·Health Affairs·John Billings, Tod Mijanovich
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Steven R CounsellGretchen D Ricketts
Jul 16, 2008·Journal of Clinical Epidemiology·Mary E CharlsonJames P Hollenberg
Jun 10, 2009·BMC Health Services Research·Stuart HowellStephen Duckett
Dec 17, 2009·Journal of General Internal Medicine·Omar HasanJeffrey L Schnipper
Mar 3, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Carl van WalravenAlan J Forster
Mar 15, 2011·Journal of General Internal Medicine·Nazima AllaudeenArpana R Vidyarthi
Aug 17, 2011·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Yan SunEillyne Seow
Oct 18, 2011·Medical Care·Klaus W LemkeJeanne M Clark
Oct 20, 2011·JAMA : the Journal of the American Medical Association·Devan KansagaraSunil Kripalani
Mar 14, 2012·Annals of Family Medicine·Martin FortinHeather Maddocks
Apr 25, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·T Lehnert, H-H König
Jun 26, 2012·European Journal of Internal Medicine·Antonio ZapateroJesus Canora
Aug 11, 2012·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Eun Whan Lee
Feb 27, 2013·Journal of Public Health·T ChenoreP H Evans
Jul 11, 2013·BMC Health Services Research·Juan F OruetaSantiago Esnaola
Mar 19, 2014·Journal of the American Geriatrics Society·Theodore K MalmstromJohn E Morley
Jun 11, 2014·Revista española de salud pública·Juan F Orueta MendiaRoberto Nuño-Solinis

❮ Previous
Next ❯

Citations

Feb 15, 2016·Journal of Diabetes and Its Complications·Diana Hedevang ChristensenHenrik Toft Sørensen
Oct 30, 2016·Journal of Clinical Pharmacy and Therapeutics·J E ChungH S Gwak
Sep 14, 2016·Biomédica : revista del Instituto Nacional de Salud·Julián Alfredo Fernández-Niño, Eduardo Bustos-Vázquez
Oct 3, 2019·BMC Medicine·Alberto ZucchelliDebora Rizzuto
May 29, 2019·Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality·Mark E CowenJennifer L Czerwinski
Jul 31, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Janet L MacNeil-VroomenHeather G Allore
Dec 13, 2017·Journal of the American Geriatrics Society·Lynn S BorkenhagenPaul Y Takahashi
Dec 15, 2019·International Journal of Environmental Research and Public Health·Katie PalmerGraziano Onder
Feb 7, 2021·Postgraduate Medical Journal·María Matesanz-FernándezEmilio Casariego-Vales
Oct 17, 2020·Journal of Clinical Epidemiology·Ana I González-GonzálezChristiane Muth
Apr 2, 2021·Open Access Emergency Medicine : OAEM·Torgny WessmanOlle Melander
Jul 13, 2021·The Journal of Surgical Research·Martha RuizNima Toosizadeh
Aug 22, 2021·Internal and Emergency Medicine·Torgny WessmanOlle Melander
Sep 2, 2021·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Bruno Pereira NunesAlexandre Dias Porto Chiavegatto Filho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.