Multimorbidity Patterns, Frailty, and Survival in Community-Dwelling Older Adults

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Quoc Dinh NguyenDae Hyun Kim

Abstract

Frailty and multimorbidity are independent prognostic factors for mortality, but their interaction has not been fully explored. We investigated the importance of multimorbidity patterns in older adults with the same level of frailty phenotype. In a cohort of 7197 community-dwelling adults 65 years and older, physical frailty status (robust, pre-frail, frail) was defined using shrinking, exhaustion, inactivity, slowness, and weakness. Latent class analysis was used to identify individuals with multimorbidity patterns based on 10 self-reported chronic conditions. We estimated hazard ratios (HR) and incidence rate differences (IRD) for mortality comparing multimorbidity patterns within each frailty state. Five multimorbidity classes were identified: minimal disease (24.7%), cardiovascular disease (29.0%), osteoarticular disease (27.3%), neuropsychiatric disease (8.9%), and high multisystem morbidity (10.0%). Within each frailty state, the mortality rate per 1000 person-years over 4 years was greatest in the neuropsychiatric class and lowest in the minimal disease class: robust (56.3 vs 15.7; HR, 2.11 [95%CI: 1.05, 4.21]; IRD, 24.1 [95%CI: -11.2, 59.3]), pre-frail (85.3 vs 40.4; HR, 1.74 [95%CI: 1.28, 2.37]; IRD, 27.1 [95%CI: 7.6, ...Continue Reading

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Citations

Aug 14, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shan-Shan YaoBeibei Xu
Sep 23, 2020·International Journal of Environmental Research and Public Health·José M TomásIrene Fernández
Jun 30, 2019·Journal of the American Geriatrics Society·Maria Theresa D OpinaWendy C Moore
Nov 26, 2020·Journal of the American Geriatrics Society·Brianne L Olivieri-MuiDae H Kim
Dec 4, 2020·Journal of the American Geriatrics Society·Mark A EspelandXavier Pi-Sunyer
Nov 7, 2020·Journal of the American Geriatrics Society·Quoc Dinh NguyenChristina Wolfson
Jan 6, 2021·Alzheimer's Research & Therapy·Linzy BohnRoger A Dixon
Apr 20, 2021·Frontiers in Genetics·Ioanna V PapathanasiouKonstantinos I Gourgoulianis
Jun 24, 2021·Chronic Illness·Tara C KlinedinstJuleen Rodakowski

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