Multimorbidity patterns in relation to polypharmacy and dosage frequency: a nationwide, cross-sectional study in a Japanese population

Scientific Reports
Takuya AokiShunichi Fukuhara

Abstract

In the present study, we aimed to identify multimorbidity patterns in a Japanese population and investigate whether these patterns have differing effects on polypharmacy and dosage frequency. Data was collected on 17 chronic health conditions via nationwide cross-sectional survey of 3,256 adult Japanese residents. Factor analysis was performed to identify multimorbidity patterns, and associations were determined with excessive polypharmacy [concurrent use of ≥ 10 prescription or over-the-counter (OTC) medications] and higher dosage frequency ( ≥ 3 doses per day). Secondary outcomes were the number of concurrent prescription medications and the number of concurrent OTC medications. We used a generalized linear model to adjust for individual sociodemographic characteristics. Five multimorbidity patterns were identified: cardiovascular/renal/metabolic, neuropsychiatric, skeletal/articular/digestive, respiratory/dermal, and malignant/digestive/urologic. Among these patterns, malignant/digestive/urologic and cardiovascular/renal/metabolic patterns showed the strongest associations with excessive polypharmacy and the number of concurrent OTC medications. Malignant/digestive/urologic, respiratory/dermal, and skeletal/articular/digesti...Continue Reading

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Citations

Feb 6, 2019·International Journal of Clinical Pharmacy·Takuya AokiShunichi Fukuhara
Feb 23, 2020·Family Practice·Hirotomo YamanashiTakahiro Maeda
Oct 31, 2019·BMC Family Practice·Shuhei YoshidaTakahiro Maeda
Aug 10, 2019·Geriatrics & Gerontology International·Masafumi Kuzuya
Mar 10, 2020·Family Medicine and Community Health·Takuya AokiShunichi Fukuhara
Oct 19, 2019·European Journal of Epidemiology·Ljoudmila BusijaMarita P McCabe
Jul 21, 2020·Journal of Pain and Symptom Management·Jun MiyashitaYosuke Yamamoto
Nov 14, 2020·International Journal of Environmental Research and Public Health·Liang-Yu ChenChien-An Sun
May 1, 2021·International Journal of Environmental Research and Public Health·Sara MucherinoAlexandra Prados-Torres
Jun 3, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·T KogameY Yamamoto
Jul 19, 2021·Research in Social & Administrative Pharmacy : RSAP·Kadesha A JamesSara J T Guilcher
Sep 28, 2021·British Journal of Clinical Pharmacology·Andrés Enríquez-GómezJosé M de Miguel-Yanes
Nov 30, 2021·Basic & Clinical Pharmacology & Toxicology·Mette Østergaard ThunboLars Henning Pedersen

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