Multinuclear NMR in polypeptide liquid crystals: Three fertile decades of methodological developments and analytical challenges

Progress in Nuclear Magnetic Resonance Spectroscopy
Philippe LesotOlivier Lafon

Abstract

NMR spectroscopy of oriented samples makes accessible residual anisotropic intramolecular NMR interactions, such as chemical shift anisotropy (RCSA), dipolar coupling (RDC), and quadrupolar coupling (RQC), while preserving high spectral resolution. In addition, in a chiral aligned environment, enantiomers of chiral molecules or enantiopic elements of prochiral compounds adopt different average orientations on the NMR timescale, and hence produce distinct NMR spectra or signals. NMR spectroscopy in chiral aligned media is a powerful analytical tool, and notably provides unique information on (pro)chirality analysis, natural isotopic fractionation, stereochemistry, as well as molecular conformation and configuration. Significant progress has been made in this area over the three last decades, particularly using polypeptide-based chiral liquid crystals (CLCs) made of organic solutions of helically chiral polymers (as PBLG) in organic solvents. This review presents an overview of NMR in polymeric LCs. In particular, we describe the theoretical tools and the major NMR methods that have been developed and applied to study (pro)chiral molecules dissolved in such oriented solvents. We also discuss the representative applications illust...Continue Reading

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Citations

Jul 8, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Boris GouilleuxPhilippe Lesot
Nov 18, 2020·Progress in Nuclear Magnetic Resonance Spectroscopy·Serge Akoka, Gérald S Remaud

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