Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases.

Virchows Archiv : an International Journal of Pathology
Gaetano MagroMichal Michal

Abstract

Multinucleated floret-like giant cells (MNFGCs), similar to those commonly observed in pleomorphic lipoma and giant cell fibroblastoma, have been occasionally reported in gynecomastia and neurofibromas from patients affected by neurofibromatosis type 1 (NF1). Accordingly, it has been suggested that their detection, especially in an otherwise typical neurofibroma, could be a morphological clue to diagnosis of NF1. The aim of the present study was the identification of MNFGCs in a large series (94 cases) of sporadic and NF1-associated neurofibromas, to assess if their presence may indeed be a morphological marker of NF1. Numerous MNFGCs, namely, those that were easily apparent at low magnification (x50 and x100), were identified only in 5.3% of cases. In 18.1% of cases, a low number of these cells could be observed but only after a careful search, especially at higher magnification (x200 and x400). Immunohistochemically, all MNFGCs were stained with vimentin and CD34, but not with S-100 protein. Interestingly, there was no statistically significant correlation between MNFGCs (presence or absence) and NF1 (p = 0.73), gender (p = 0.59), age (p = 0.43), and site of tumor (cutaneous vs deep-seated soft tissue; p = 0.27). Our clinicop...Continue Reading

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Citations

May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jennifer BlackLouis P Dehner
Jun 20, 2014·Indian Journal of Pathology & Microbiology·Sinai Khandeparkar Siddhi GaurishAvinash Joshi
Jan 19, 2013·Seminars in Diagnostic Pathology·José Luis Rodríguez-PeraltoRosario Carrillo
May 17, 2014·The American Journal of Pathology·Eric P RahrmannDavid A Largaespada
Apr 25, 2012·American Journal of Medical Genetics. Part a·Juliette PiardBruno Leheup
Dec 24, 2014·Clinical and Experimental Dermatology·E J KimS Cho
Aug 25, 2020·Current Opinion in Neurology·Anders Meyer
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Apr 3, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Louis P Dehner, Alejandro A Gru
Jun 21, 2020·International Journal of Molecular Sciences·Lucio Díaz-FloresJosé Luis Carrasco
Jun 10, 2017·Head and Neck Pathology·Tatiana Fernandes Araújo AlmeidaJorge Esquiche León
Jan 19, 2021·Journal of Oral and Maxillofacial Pathology : JOMFP·Sudeendra PrabhuMohitha Shetty

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