Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer

Journal of Clinical Medicine
Subbroto Kumar SahaKyoung Sik Park


Kidney-type glutaminase (GLS) and liver-type glutaminase (GLS2) are dysregulated in many cancers, making them appealing targets for cancer therapy. However, their use as prognostic biomarkers is controversial and remains an active area of cancer research. Here, we performed a systematic multiomic analysis to determine whether glutaminases function as prognostic biomarkers in human cancers. Glutaminase expression and methylation status were assessed and their prominent functional protein partners and correlated genes were identified using various web-based bioinformatics tools. The cross-cancer relationship of glutaminases with mutations and copy number alterations was also investigated. Gene ontology (GO) and pathway analysis were performed to assess the integrated effect of glutaminases and their correlated genes on various cancers. Subsequently, the prognostic roles of GLS and GLS2 in human cancers were mined using univariate and multivariate survival analyses. GLS was frequently over-expressed in breast, esophagus, head-and-neck, and blood cancers, and was associated with a poor prognosis, whereas GLS2 overexpression implied poor overall survival in colon, blood, ovarian, and thymoma cancers. BothGLS and GLS2 play oncogenic ...Continue Reading


Feb 27, 1999·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T NagaseO Ohara
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A BhattacharjeeM Meyerson
Jun 5, 2002·Physiological Genomics·L David PorterNorman P Curthoys
Mar 26, 2003·The American Journal of Pathology·Christine A Iacobuzio-DonahueMichael Goggins
Mar 23, 2004·Molecular Biology of the Cell·Hongjuan ZhaoStefanie S Jeffrey
Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Oct 2, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian HaslingerRoger Abseher
Nov 30, 2005·The American Journal of Pathology·Robert S StearmanMark W Geraci
Jan 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marta Sanchez-CarbayoCarlos Cordon-Cardo
Feb 17, 2007·The Journal of Clinical Investigation·Pier Paolo PiccalugaStefano A Pileri
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anastasia MuratMonika E Hegi
Dec 17, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mariarosaria D'ErricoEugenia Dogliotti
Apr 28, 2009·BMC Medical Genomics·Hideaki MizunoAkinori Sarai
Jul 2, 2009·Genome Medicine·Adam Shlien, David Malkin
Dec 17, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnaud D RothFred Bosman
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sawako SuzukiCarol Prives
Apr 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wenwei HuZhaohui Feng
Sep 14, 2010·Cancer Cell·Jian-Bin WangRichard A Cerione
Dec 8, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Mallavarapu R SrividyaVani Santosh
May 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Audrey VincentMichael Goggins
Jun 23, 2011·Cancer Informatics·Gwangsik ShinSeon-Young Kim
Jan 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alexandre CassagoAndre L B Ambrosio
Sep 1, 2012·Current Molecular Medicine·J M MatésJavier Márquez
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Jul 23, 2013·Nature Protocols·Huaiyu MiPaul D Thomas
Dec 18, 2013·BMC Cancer·Jianbin ZhangDajing Xia
Feb 14, 2014·Molecular Cancer Therapeutics·Matt I GrossMark K Bennett


Jan 7, 2020·The Laryngoscope·Hsiu-Wen TsaiAlexander T Hillel
Jul 19, 2020·Archives of Toxicology·J M MatésJavier Márquez
Apr 25, 2020·International Journal of Molecular Sciences·Yunuen Ortiz-PedrazaMarcela Lizano
Oct 9, 2020·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Pegah FarhadiKamran Mansouri
Dec 11, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Ju-Yueh LiKuan-Hao Tsui
Feb 2, 2021·Journal of Diabetes and Metabolic Disorders·Lakshmipathi VadlakondaAramati B M Reddy
Mar 22, 2021·Frontiers in Cell and Developmental Biology·Xi-Min HuKun Xiong

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.