Multiorgan-protective actions of blockers of the renin-angiotensin system, statins and erythropoietin: common pleiotropic effects in reno-, cardio- and neuroprotection

Acta Clinica Belgica
G GluhovschiG Bozdog

Abstract

Renal diseases induce nephroprotective measures that may affect the heart, brain and other organs. In addition, many cardiovascular and neurological diseases are accompanied by renal lesions. For these reasons, multiorgan-protective measures, including cardio-, reno- and neuro-protective measures, are necessary to treat these diseases. The drugs used in nephrology are often pleiotropic. Although they usually address a single organ or tissue, many of them have complex actions that may provide multiorgan-protection. The present paper aims to review 3 classes of drugs that are commonly prescribed in nephrological practice: statins, RAS blockers (such as ACEIs and ARBs) and erythropoietin (EPO). This paper highlights the renoprotective actions, as well as those that are protective of the heart, brain and other organs, of these drugs at the cellular and molecular level. Their protective actions are attributable to their main effects and pleiotropic effects. The protective pleiotropic actions of these drugs may be exerted on multiple organs, making them multiorgan-protective. Another objective is to analyse the shared multiorgan-protective pleiotropic effects of RAS blockers (ACEIs and ARBs), statins and erythropoietin. This will all...Continue Reading

References

Mar 1, 1995·Kidney International·R G CarliniM Rothstein
Nov 1, 1993·Kidney International·P H MaxwellP J Ratcliffe
Apr 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E HessG Stein
Jun 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S AlbitarB Bourgeon
Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
Jul 21, 1999·Kidney International. Supplement·A YoshimuraT Ideura
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C G ChewA P Disney
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A K Abu-AlfaM J Bia
Feb 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J FinkP Light
Jun 8, 2001·Seminars in Oncology·L Mulcahy
Nov 8, 2001·European Archives of Psychiatry and Clinical Neuroscience·A L Sirén, H Ehrenreich
Jan 25, 2002·Annals of the New York Academy of Sciences·R J GryglewskiJ Madej
Feb 9, 2002·British Journal of Pharmacology·Jacob Bertram SpringborgNiels Vidiendal Olsen
Apr 23, 2002·Kidney International·Carla ZojaGiuseppe Remuzzi
May 1, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tsukasa NakamuraHikaru Koide
Jun 1, 2002·Journal of the American Society of Nephrology : JASN·Wulf Palinski, Sotirios Tsimikas
Jun 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alfredo GorioMichael Brines
Aug 3, 2002·Hypertension·Sandrine DelboscBernard Jover
Aug 17, 2002·Clinical Therapeutics·Maria-Teresa Zanella, Artur B Ribeiro
Sep 25, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Colin H JonesDonald Richardson
Oct 9, 2002·Angiology·Moses Elisaf, Dimitri P Mikhailidis
Oct 17, 2002·Experimental Nephrology·Christof Westenfelder
Nov 22, 2002·Journal of the American Society of Nephrology : JASN·Carla ZojaGiuseppe Remuzzi
Nov 29, 2002·Stem Cells·Terence R LappinPatrick G Johnston
Mar 15, 2003·Internal Medicine·Ryuzo Sasaki
Mar 18, 2003·Journal of Neuropathology and Experimental Neurology·M BuemiN Frisina
May 23, 2003·Journal of the American Society of Nephrology : JASN·Marcello TonelliUNKNOWN Cholesterol and Recurrent Events Trial Investigators
Sep 13, 2003·Kidney International·Barry M Brenner
Nov 19, 2003·Current Opinion in Lipidology·Adriane Skaletz-Rorowski, Kenneth Walsh
Nov 25, 2003·Kidney International·Arrigo Schieppati, Giuseppe Remuzzi
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ferdinand H BahlmannDanilo Fliser
Jan 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David A VeseyDavid W Johnson
Feb 27, 2004·European Heart Journal·Peter van der MeerDirk J van Veldhuisen
Apr 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gary L WrightMurat O Arcasoy
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Farhad R Danesh, Yashpal S Kanwar
Jun 9, 2004·Hypertension·Kwang Kon KohEak Kyun Shin
Jun 18, 2004·Kidney International·Juliane Heusinger-RibeiroMargarete Goppelt-Struebe

❮ Previous
Next ❯

Citations

Sep 17, 2011·Internal Medicine·Nobuharu FujiwaraKoichi Node
Jun 17, 2011·Anaesthesia and Intensive Care·E M MooreA D Nichol

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Nephrology and Hypertension
Cristina Sierra, Alejandro de la Sierra
Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne
G GluhovschiLigia Petrica
Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Nasreen A Al-SayedRobert S Zimmerman
© 2022 Meta ULC. All rights reserved