Multiparametric analysis of cerebral substrates and nitric oxide delivery in cerebrospinal fluid in patients with intracerebral haemorrhage: correlation with hemodynamics and outcome

Acta neurochirurgica
M-F ChiangS-H Tsai

Abstract

There is no information regarding the possible role of cerebral substrates in the pathogenesis of neuronal injury in intracerebral haemorrhages (ICHs). Purposes of this prospective study were to clarify whether changes in substrates are the consequence of the initial brain damage in ICH and to elucidate the relationship among the biochemical mechanisms and clinical course of patients with ICH. During a period of two years, patients (GCS < or =8) who had ICH secondary to an aneurysm (SAH), stroke (sICH), or trauma (tICH) and underwent ventriculostomy with ICP monitoring and/or underwent cranial surgery were randomly enrolled in this study. Extracellular concentrations of glutamate, aspartate, glycine, GABA, lactate, lactate/pyruvate ratio, and glucose in the CSF were measured by use of high-performance liquid chromatography (HPLC). The nitric oxide (NO) concentration in the CSF was analyzed by chemiluminescence. There were 75 patients (38 women and 37 men) with ICH included in this study. Twenty-one patients had SAH, 28 sICH, and 26 tICH. In tICH patients, there was a 30-fold increase in glutamate and a 10-fold in aspartate over reference values. The levels of glutamate, aspirate, GABA, lactate, glucose, and NO differed signific...Continue Reading

References

Sep 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·R Kanthan, A Shuaib
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Oct 7, 1998·Journal of Neurosurgery·R BullockH F Young
Jan 15, 2000·Acta Neurochirurgica. Supplement·T YamamotoA Marmarou
Jul 7, 2000·Journal of Neurosurgery·P J HutchinsonJ D Pickard
Feb 13, 2001·Methods : a Companion to Methods in Enzymology·A Mendelowitsch
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Aug 29, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O W SakowitzA W Unterberg
Jan 29, 2005·Acta Anaesthesiologica Scandinavica·C-J HuangJ W Skimming

❮ Previous
Next ❯

Citations

Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Noboru TodaTomio Okamura
Jan 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marius M MaderJuliane Hannemann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.