Abstract
There is no information regarding the possible role of cerebral substrates in the pathogenesis of neuronal injury in intracerebral haemorrhages (ICHs). Purposes of this prospective study were to clarify whether changes in substrates are the consequence of the initial brain damage in ICH and to elucidate the relationship among the biochemical mechanisms and clinical course of patients with ICH. During a period of two years, patients (GCS < or =8) who had ICH secondary to an aneurysm (SAH), stroke (sICH), or trauma (tICH) and underwent ventriculostomy with ICP monitoring and/or underwent cranial surgery were randomly enrolled in this study. Extracellular concentrations of glutamate, aspartate, glycine, GABA, lactate, lactate/pyruvate ratio, and glucose in the CSF were measured by use of high-performance liquid chromatography (HPLC). The nitric oxide (NO) concentration in the CSF was analyzed by chemiluminescence. There were 75 patients (38 women and 37 men) with ICH included in this study. Twenty-one patients had SAH, 28 sICH, and 26 tICH. In tICH patients, there was a 30-fold increase in glutamate and a 10-fold in aspartate over reference values. The levels of glutamate, aspirate, GABA, lactate, glucose, and NO differed signific...Continue Reading
References
Sep 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·R Kanthan, A Shuaib
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Apr 1, 1996·Journal of Neurosurgery·L PerssonL Hillered
Oct 8, 1997·Neurosurgery·Y SuzukiJ Yoshida
Nov 15, 1997·Neurosurgery·A ZaunerR Bullock
Dec 31, 1997·Journal of Neurosurgery·E M DoppenbergR Bullock
Jul 23, 1998·Journal of Neurotrauma·A B ValadkaC S Robertson
Oct 7, 1998·Journal of Neurosurgery·R BullockH F Young
Dec 2, 1998·Journal of Neurosurgery·P VespaD P Becker
Oct 3, 1999·Journal of Neurosurgery·I FriedL Ackerson
Jan 15, 2000·Acta Neurochirurgica. Supplement·T YamamotoA Marmarou
Jan 15, 2000·Acta Neurochirurgica. Supplement·B AlessandriH F Young
Feb 25, 2000·Neuroscience Letters·Y J LaiW H Pan
Mar 18, 2000·Journal of Chromatography. a·F C ChengS H Chen
Jul 7, 2000·Journal of Neurosurgery·P J HutchinsonJ D Pickard
Nov 4, 2000·Journal of Neurosurgery·M K SchulzP Bjerre
Nov 4, 2000·Neurosurgery·F StaubW D Heiss
Feb 13, 2001·Methods : a Companion to Methods in Enzymology·A Mendelowitsch
Feb 15, 2001·Critical Care Medicine·D SadamitsuT Maekawa
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Aug 29, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O W SakowitzA W Unterberg
Sep 21, 2001·Acta Neurochirurgica. Supplement·M ReinertR Bullock
Jan 5, 2002·Surgical Neurology·M UzanC Kuday
May 17, 2003·Stroke; a Journal of Cerebral Circulation·Asita SarrafzadehAndreas Unterberg
May 29, 2003·Critical Care Medicine·Adnan I QureshiL Nelson Hopkins
Jan 29, 2005·Acta Anaesthesiologica Scandinavica·C-J HuangJ W Skimming
Citations
Dec 17, 2010·Neurocritical Care·Guofeng WuZhen Hong
Aug 21, 2013·SpringerPlus·Guofeng WuFan Wang
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Noboru TodaTomio Okamura
Apr 15, 2014·Neuroscience·A LuJ F Clark
Oct 23, 2009·Annals of Neurology·Frauke OttoMarcel Dihné
Jun 15, 2011·Neurological Research·Na LiKarin Weissenborn
Jun 5, 2012·Brain Research·Guofeng WuFan Wang
Nov 28, 2012·Brain Research·Guofeng WuFei Sheng
Dec 15, 2017·Journal of Neuroinflammation·Hans WorthmannKarin Weissenborn
Jan 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marius M MaderJuliane Hannemann
Feb 1, 2022·Current Medical Science·Kuldeep Singh JadaunNaif Alsuhaymi