Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer's disease.

European Journal of Nuclear Medicine and Molecular Imaging
Shaozhen YanJie Lu

Abstract

The objective of this study is to investigate the hippocampal neurodegeneration and its associated aberrant functions in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients using simultaneous PET/MRI. Forty-two cognitively normal controls (NC), 38 MCI, and 22 AD patients were enrolled in this study. All subjects underwent 18F-FDG PET/functional MRI (fMRI) and high-resolution T1-weighted MRI scans on a hybrid GE Signa PET/MRI scanner. Neurodegeneration in hippocampus and its subregions was quantified by regional gray matter volume and 18F-FDG standardized uptake value ratio (SUVR) relative to cerebellum. An iterative reblurred Van Cittert iteration method was used for voxelwise partial volume correction on 18F-FDG PET images. Regional gray matter volume was estimated from voxel-based morphometric analysis with MRI. fMRI data were analyzed after slice time correction and head motion correction using statistical parametric mapping (SPM12) with DPARSF toolbox. The regions of interest including hippocampus, cornu ammonis (CA1), CA2/3/dentate gyrus (DG), and subiculum were defined in the standard MNI space. Patient groups had reduced SUVR, gray matter volume, and functional connectivity compared to NC in CA1, CA2/3/...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Jan 10, 2006·Neurobiology of Aging·Armin von GuntenPanteleimon Giannakopoulos
Jun 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Travis R StoubRaj C Shah
Oct 10, 2007·Archives of Neurology·Greg AllenC Munro Cullum
Jun 26, 2010·Frontiers in Systems Neuroscience·Yan Chao-Gan, Zang Yu-Feng
Dec 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Deepti PutchaReisa Sperling
Feb 21, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie E WintzerThomas J McHugh
May 16, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Milagros S CoparaArne D Ekstrom
Jul 22, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lorenzo PasquiniChristian Sorg
Jun 15, 2015·Progress in Brain Research·John P Aggleton, Kat Christiansen
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Xiaoying TangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 27, 2016·Physics in Medicine and Biology·Benjamin A ThomasKjell Erlandsson
Jan 1, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David H AdamowiczFred H Gage
Apr 20, 2017·Hippocampus·Catherine A ThornJeremy R Edgerton
Jul 29, 2017·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Diego CecchinAlessandra Bertoldo
Feb 13, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jens GöttlerChristian Sorg
Mar 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Daniel H AdlerPaul A Yushkevich
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors
Apr 18, 2019·NeuroImage. Clinical·Manish D ParanjpeUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 6, 2019·NeuroImage. Clinical·Christian LaKathleen L Poston

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Citations

May 1, 2021·International Journal of Molecular Sciences·Mootaz M SalmanRichard Wade-Martins
May 23, 2021·Seminars in Nuclear Medicine·Asim AfaqJamshed Bomanji
Apr 21, 2021·Brain : a Journal of Neurology·Shaozhen YanUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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Software Mentioned

DPARSF
Data Processing Assistant for Resting fMRI ( DPARSF )
Statistical Analysis System ( SAS
DPARSF CAT12
DARTEL
SPM12
CAT12
SPM Anatomy Toolbox
BrainNet Viewer

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