Multiparametric magnetic resonance imaging of the prostate can improve the predictive value of the urinary prostate cancer antigen 3 test in patients with elevated prostate-specific antigen levels and a previous negative biopsy

BJU International
Alessandro SciarraStefano Salciccia

Abstract

Study Type--Clinical (prospective trial) Level of Evidence 2b. What's known on the subject? and What does the study add? In clinical practice, we know that it is necessary to identify new biomarkers that can better detect prostate cancer (PC), at the same time as reducing the number of unnecessary biopsies. Recently, studies have suggested that the most relevant clinical scenario in which the prostate cancer antigen 3 (PCA3) score could be used comprises patients with a previous negative prostate biopsy and persistently elevated PSA levels. At the same time, although multiparametric MRI is not currently used as a first approach for diagnosing PC, it can be useful for directing targeted biopsies, especially in those patients with elevated PSA levels and a previous negative TRUS-guided biopsy. Considering all of these aspects, the present study aimed to evaluate the role of multiparametric MRI as an additional diagnostic tool for improving the accuracy of the urinary PCA3 test in patients with increased PSA levels and a previous negative prostate biopsy. Our hypothesis is that the potential value of the PCA3 test as a biomarker for PC diagnosis could be improved by the use of multiparametric MRI in directing prostate biopsy. In t...Continue Reading

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Citations

Apr 3, 2014·Iranian Red Crescent Medical Journal·Mahyar GhafooriMounes Aliyari Ghasabeh
Feb 22, 2014·Der Radiologe·K PinkerP Baltzer
Dec 20, 2014·BioMed Research International·Philippe PuechLaurent Lemaitre
Oct 2, 2013·Urology·Gian Maria BusettoValeria Panebianco
Jan 31, 2017·Academic Radiology·Angela GiardinoDhakshinamoorthy Ganeshan
Jan 9, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Daniel A ShoskesEdmund Sabanegh
Jun 14, 2013·International Journal of Molecular Sciences·Gisele H J M LeytenPeter F A Mulders
Jul 19, 2018·Expert Review of Anticancer Therapy·Guillaume Ploussard, Alexandre de la Taille
Jan 22, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Zhiqiang QinRuipeng Jia
May 1, 2021·International Journal of Molecular Sciences·Stefano SalcicciaMartina Maggi

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