Multiparametric MR imaging reveals early cartilage degeneration at 2 and 8 weeks after ACL transection in a rabbit model

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Abdul Wahed KajabiM T Nieminen

Abstract

In this study, the rabbit model with anterior cruciate ligament transection (ACLT) was used to investigate early degenerative changes in cartilage using multiparametric quantitative magnetic resonance imaging (qMRI). ACLT was surgically induced in the knees of skeletally mature New Zealand White rabbits (n = 14). ACL transected and contralateral knee compartments-medial femur, lateral femur, medial tibia, and lateral tibia-were harvested 2 (n = 8) and 8 weeks (n = 6) postsurgery. Twelve age-matched nonoperated rabbits served as control. qMRI was conducted at 9.4 T and included relaxation times T1 , T2 , continuous-wave T1ρ (CWT1ρ ), adiabatic T1ρ (AdT1ρ ), adiabatic T2ρ (AdT2ρ ), and relaxation along a fictitious field (TRAFF ). For reference, quantitative histology and biomechanical measurements were carried out. Posttraumatic changes were primarily noted in the superficial half of the cartilage. Prolonged T1 , T2 , CWT1ρ , and AdT1ρ were observed in the lateral femur 2 and 8 weeks post-ACLT, compared with the corresponding control and contralateral groups (P < .05). Collagen orientation was significantly altered in the lateral femur at 2 weeks post-ACLT compared with the corresponding control group. In the medial femur, all t...Continue Reading

References

Jan 1, 1975·Clinical Orthopaedics and Related Research·H Troyer
Nov 1, 1985·Journal of Computer Assisted Tomography·R E SepponenJ I Tanttu
Jun 1, 1996·Osteoarthritis and Cartilage·M YoshiokaS A Hacker
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y Xia
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S V AkellaR Reddy
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M T NieminenJ S Jurvelin
Dec 13, 2001·Journal of Magnetic Resonance·M Garwood, L DelaBarre
Feb 16, 2002·Cellular and Molecular Life Sciences : CMLS·E Hedbom, H J Häuselmann
Jan 2, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Olli H J GröhnRisto A Kauppinen
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sarma V S AkellaRavinder Reddy
Jul 19, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·David L GushueAmy L Lerner
Mar 9, 2006·Journal of Magnetic Resonance Imaging : JMRI·Ravinder R RegatteRavinder Reddy
Jan 19, 2008·Medicine and Science in Sports and Exercise·Ajit M W ChaudhariThomas P Andriacchi
Dec 6, 2008·Magnetic Resonance Imaging·Jatta E BerberatMiika T Nieminen
Dec 6, 2008·Magnetic Resonance Imaging·Jesus LozanoC Benjamin Ma
Jun 13, 2009·Arthritis Research & Therapy·Steven B Abramson, Mukundan Attur
Aug 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Timo LiimatainenShalom Michaeli
Jun 15, 2011·The Journal of Cell Biology·Bradley S DeMayAmy S Gladfelter
Oct 20, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Henning MadryAndrea Facchini
Jun 9, 2015·Osteoarthritis and Cartilage·A GuermaziF W Roemer
Dec 15, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Mikko J NissiMiika T Nieminen
Sep 28, 2016·Bone Research·David M Findlay, Julia S Kuliwaba
Aug 31, 2017·Scientific Reports·Nina HänninenMikko Johannes Nissi
Jul 22, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley A WilliamsConstance R Chu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.