Multiparity affects conduction properties of pelvic floor nerves in rabbits

Brain and Behavior
F CastelánM Martínez-Gómez

Abstract

Women often develop pelvic floor dysfunction due to damage to the pelvic musculature during childbirth; however, the effect on pelvic floor nerves function is less understood. This study used adult rabbits to evaluate the electrophysiological and histological characteristics of the bulbospongiosus (Bsn) and pubococcygeus nerves (Pcn) in multiparity. Compound nerve action potentials (CNAP) were compared between age-matched nulliparous and multiparous animals and associated to the histological characteristics of myelinated axons from the Bsn and Pcn nerves. The extensor digitorum longus nerve (EDLn) was used as negative control. Data were analyzed with unpaired two-tailed Student's t test or Mann-Whitney U test to determine significant differences between groups. The onset and peak latencies, duration, and conduction velocity of the motor fibers in these pelvic nerves were not significantly different between nulliparous and multiparous animals. However, the peak-to-peak amplitude and area of the CNAP in both Bsn and Pcn were reduced in multiparous rabbits. Histology showed a higher percentage of axons with myelin disorganization caused by multiparity in these pelvic nerves. Together, the data indicate a reduction in the number of...Continue Reading

References

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Aug 13, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Francisco CastelánMargarita Martínez-Gómez
Feb 7, 2014·Neurourology and Urodynamics·Qi-Xiang SongHai-Hong Jiang
Dec 3, 2014·Neurourology and Urodynamics·Kenia López-GarcíaFrancisco Castelán
Jan 20, 2017·Neurourology and Urodynamics·Yolanda CruzMargarita Martínez-Gómez
May 26, 2017·Neurourology and Urodynamics·Rhode López-JuárezMargarita Martínez-Gómez

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Citations

Feb 2, 2019·International Urogynecology Journal·Octavio Sánchez-GarcíaFrancisco Castelán
May 21, 2021·Scientific Reports·Ana G Hernandez-ReynosoMario I Romero-Ortega

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Methods Mentioned

BETA
light microscopy
electron microscopy

Software Mentioned

GraphPad
GraphPad Prism

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