Multiplatform plasma fingerprinting in cancer cachexia: a pilot observational and translational study

Journal of Cachexia, Sarcopenia and Muscle
Mónica P CalaJose Antonio Lopez-Martin

Abstract

Cachexia is a metabolic syndrome that affects up to 50-80% of cancer patients. The pathophysiology is characterized by a variable combination of reduced food intake and abnormal metabolism, including systemic inflammation and negative protein and energy balance. Despite its high clinical significance, defined diagnostic criteria and established therapeutic strategies are lacking. The 'omics' technologies provide a global view of biological systems. We hypothesize that blood-based metabolomics might identify findings in cachectic patients that could provide clues to gain knowledge on its pathophysiology, and eventually postulate new therapeutic strategies. This is a cross-sectional observational study in two cohorts of cancer patients, with and without cachexia. Patients were consecutively recruited from routine clinical practice of a General Oncology Department at '12 de Octubre' University Hospital. Selected clinical and biochemical features were collected. Blood metabolite fingerprinting was performed using three analytical platforms, gas chromatography coupled to mass spectrometry (GC-MS), capillary electrophoresis coupled to mass spectrometry (CE-MS), and liquid chromatography coupled to mass spectrometry (LC-MS). Besides, ...Continue Reading

References

Jan 1, 1974·Cancer·C Waterhouse
Jan 1, 1993·Critical Reviews in Clinical Laboratory Sciences·P W Pisters, D B Pearlstone
Apr 3, 1999·Lipids·T SasagawaA Watanabe
Jan 29, 2000·The American Journal of Clinical Nutrition·S Leij-HalfwerkJ P Wilson
Feb 29, 2000·Nutrition and Cancer·D E RivadeneiraJ M Daly
Jul 26, 2000·Metabolism: Clinical and Experimental·S D Zuijdgeest-van LeeuwenP C Dagnelie
Apr 8, 2006·The American Journal of Clinical Nutrition·John E MorleyMargaret-Mary G Wilson
Jun 27, 2006·Medical Hypotheses·G P A BongaertsD J Th Wagener
Jul 29, 2006·World Journal of Gastroenterology : WJG·Mariano MalaguarneraMatteo Angelo Cannizzaro
Jun 27, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Helen G GikaIan D Wilson
Aug 23, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·William J EvansStefan D Anker
Apr 4, 2009·Physiological Reviews·Michael J Tisdale
Jul 3, 2010·Internal and Emergency Medicine·Maurizio MuscaritoliFilippo Rossi Fanelli
Jul 16, 2010·Bioinformatics·Jianguo Xia, David S Wishart
Jan 7, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Luigi MarianiUNKNOWN SCRINIO Working Group
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Apr 2, 2011·Antioxidants & Redox Signaling·Mariana N Nikolova-Karakashian, Michael B Reid
Apr 9, 2011·Journal of Cachexia, Sarcopenia and Muscle·Stephan von Haehling, Stefan D Anker
Jun 3, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ioannis GioulbasanisVassilis Georgoulias
Aug 31, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sherif AwadDileep N Lobo
Oct 22, 2011·Autonomic Neuroscience : Basic & Clinical·Alpna ChauhanAndrew Wilcock
Feb 22, 2012·Journal of the National Cancer Institute·Christine BaldwinPeter W Emery
Mar 28, 2012·Journal of Cachexia, Sarcopenia and Muscle·Mary A Honors, Kimberly P Kinzig
Apr 7, 2012·Nutrition·Thorhallur AgustssonBengt Isaksson
Jul 17, 2012·Cell Metabolism·Kenneth C H FearonDenis C Guttridge
Jul 25, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·K C H Fearon
Sep 1, 2012·World Journal of Biological Chemistry·Feng Zhang, Guangwei Du
Nov 1, 2012·Current Opinion in Supportive and Palliative Care·Tora S Solheim, Barry J A Laird
Nov 6, 2012·Current Opinion in Supportive and Palliative Care·Hirak Der-TorossianMarion E Couch
Nov 10, 2012·Biochimica Et Biophysica Acta·Wim J van Blitterswijk, Marcel Verheij
Dec 5, 2012·Nature Reviews. Clinical Oncology·Kenneth FearonVickie Baracos
Mar 21, 2013·Journal of Gastroenterology·Hajime SuzukiAkio Inui
Jun 26, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Sally WheelwrightColin D Johnson
Feb 27, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AaproUNKNOWN ESMO (European School of Medical Oncology)
Jun 12, 2014·Revista da Associação Médica Brasileira·Sílvia Paredes, Laura Ribeiro
Oct 8, 2014·Nature Reviews. Cancer·Josep M ArgilésFrancisco J López-Soriano
Nov 12, 2014·Journal of Cachexia, Sarcopenia and Muscle·Stephan von Haehling, Stefan D Anker
Nov 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Dec 18, 2014·Current Topics in Medicinal Chemistry·Annalaura MastrangeloCoral Barbas
Feb 19, 2015·Frontiers in Physiology·Theodore P Braun, Daniel L Marks
Mar 20, 2015·Frontiers in Bioengineering and Biotechnology·Sean R Johnson, Bernd Markus Lange
Mar 31, 2015·Aging Clinical and Experimental Research·Antonio MartocchiaPaolo Falaschi
Apr 22, 2015·Nucleic Acids Research·Jianguo XiaDavid S Wishart
Apr 22, 2015·World Journal of Gastrointestinal Oncology·Tomoyoshi AoyagiKazuaki Takabe

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Citations

Sep 21, 2018·Electrophoresis·Rawi RamautarGerhardus J de Jong
Mar 13, 2019·American Journal of Physiology. Endocrinology and Metabolism·Juulia H LautaojaJuha J Hulmi
Dec 11, 2019·Journal of Cachexia, Sarcopenia and Muscle·Markus S AnkerStephan von Haehling
Apr 29, 2020·Scientific Reports·Mario Augusto IzidoroFrancisco J Rupérez
Mar 28, 2020·PloS One·María Martín-VicenteIsidoro Martínez
Oct 23, 2020·Journal of Cachexia, Sarcopenia and Muscle·Pauline MorignyMaria Rohm
Oct 28, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yousra Ahmed-SalimSrdjan Saso
Mar 13, 2021·Biochemical Pharmacology·Raquel D S Freitas, Maria M Campos
Aug 20, 2020·Journal of Pharmaceutical and Biomedical Analysis·Özge Cansın ZekiEmirhan Nemutlu
Apr 23, 2021·Porto Biomedical Journal·Patrícia TavaresRita Ferreira
Oct 19, 2019·Analytical Chemistry·Carolina González-RianoCoral Barbas
Aug 26, 2021·Disease Models & Mechanisms·Elia EscasanyGema Medina-Gómez
Oct 9, 2021·Frontiers in Cell and Developmental Biology·Thomas M O'ConnellAndrea Bonetto
Oct 13, 2021·Journal of Cachexia, Sarcopenia and Muscle·Silvia CataneseUlrich T Hacker

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Methods Mentioned

BETA
Feature Extraction
Profiler

Software Mentioned

Agilent MassHunter Quantitative Analysis
MathWorks
MetaboAnalyst
Unknowns Analysis Tool
Matlab
SIMCA
MassHunter Profinder
Profinder
Excel
Metabolomics Pathway

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