PMID: 3755767Oct 1, 1986Paper

Multiple 3' ends of mRNA encoding vaccinia virus growth factor occur within a series of repeated sequences downstream of T clusters

Journal of Virology
L Yuen, B Moss

Abstract

Analysis of the 5' ends of six apparently full-length cloned cDNA copies of the vaccinia virus growth factor gene suggested precise transcriptional initiation at the first purine following a run of five pyrimidines in the noncoding strand. By contrast, the 3' ends exhibited heterogeneity and were distributed over a 46-base-pair region. In each of the six cDNAs, the nucleotide immediately preceding the retained copy of the poly(A) tail corresponded to the first or second T of a TATGT repeat. Clusters of Ts occurred upstream of the 3' ends, but the AATAAA polyadenylation consensus sequence of higher eucaryotes was absent. Determination of the complete sequence of one cDNA revealed exact correspondence with the vaccinia virus growth factor gene, indicating the absence of internal RNA processing.

References

Jan 1, 1985·Journal of Virology·F Golini, J R Kates
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P L EarlB Moss
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D R TwardzikB Moss
May 25, 1981·Nucleic Acids Research·H LandG Schütz
Oct 25, 1980·Journal of Molecular Biology·F SangerB A Roe
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D E HrubyL A Ball
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M C BlomquistW C Barker

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Citations

Mar 30, 2001·The Journal of Biological Chemistry·M R Mohamed, E G Niles
Jan 31, 2003·The Journal of Biological Chemistry·Mohamed Ragaa Mohamed, Edward G Niles
Jan 8, 2000·The Journal of Biological Chemistry·C A Lackner, R C Condit
Sep 6, 2002·Biochimica Et Biophysica Acta·Richard C Condit, Edward G Niles
Jan 1, 1994·Journal of Virology·D J LyttleA J Robinson
Nov 1, 1992·Journal of Virology·F AlmazánJ F Rodriguez
Jun 1, 1988·Journal of Virology·J F Schmitt, H G Stunnenberg
Jun 23, 2004·Virology·Mohamed Ragaa Mohamed, Edward G Niles
Feb 8, 2006·Virology·Mohamed Ragaa MohamedEdward G Niles
Apr 25, 2008·Virology·Sarah PiacenteEdward G Niles

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