Multiple Actions of Phencyclidine and (+)MK-801 on Isolated Bovine Cerebral Arteries

Journal of Neurosurgical Anesthesiology
Woodrow W WendlingIhab R Kamel

Abstract

This study examines the direct effects of 3 noncompetitive N-methyl-D-aspartate receptor antagonists, phencyclidine (PCP), (+)MK-801, and (-)MK-801, on bovine middle cerebral arteries (BMCA). Rings of BMCA were mounted in isolated tissue chambers equipped with isometric tension transducers to obtain pharmacologic dose-response curves. In the absence of endogenous vasoconstrictors, the 3 N-methyl-D-aspartate antagonists each produced direct constriction of BMCA. The thromboxane A2 receptor antagonist SQ-29,548, the TxA2 synthase inhibitor furegrelate, the calcium antagonist nimodipine, and calcium-deficient media all inhibited maximal phencyclidine or (+)MK-801-induced constriction. Direct constriction by PCP or (+)MK-801 was independent of the presence of endothelium. When BMCA were preconstricted with potassium-depolarizing solution, PCP, (+)MK-801, and (-)MK-801 each produced only concentration-dependent relaxation. When BMCA were preconstricted with the stable TxA2 analog U-46,619 and exposed to increasing concentrations of PCP, (+)MK-801, or (-)MK-801, tension increased. Thromboxane A2 may contract BMCA by acting as a potassium channel blocker; iberiotoxin and tetraethylammonium both constrict BMCA. In Ca-deficient media co...Continue Reading

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Mar 1, 1992·The American Journal of Physiology·F S Scornik, L Toro
Jan 1, 1991·Stroke; a Journal of Cerebral Circulation·W W Wendling, C Harakal
Aug 4, 1987·European Journal of Pharmacology·H E Connor, W Feniuk
Dec 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P M BeartD T Manallack
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H WongL L Iversen
Jan 22, 1982·European Journal of Pharmacology·D Lodge, N A Anis
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Sep 1, 1995·Stroke; a Journal of Cerebral Circulation·T KitazonoD D Heistad
Dec 1, 1994·The American Journal of Physiology·B E Robertson, M T Nelson
Jul 1, 1994·Journal of Neurosurgical Anesthesiology·W W WendlingC Carlsson
Oct 1, 1995·Journal of Neurosurgical Anesthesiology·A W GelbJ T Hamilton
Dec 18, 1998·Journal of Neuroscience Research·I A KrizbaiF Joó
Nov 8, 2001·American Journal of Physiology. Cell Physiology·G J PérezM T Nelson
Jan 11, 2002·Neurological Research·Frantisek St'astnýDaniela Jezová
Apr 11, 2007·British Journal of Pharmacology·A J McNeish, C J Garland
Sep 2, 2008·Clinical and Experimental Pharmacology & Physiology·Manuel F Navarro-GonzalezCaryl E Hill
Nov 11, 2008·European Journal of Pharmacology·Kenneth Beri PlougInger Jansen-Olesen
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Dec 24, 2013·Progress in Neurobiology·Ted Weita LaiYu Tian Wang
Mar 29, 2014·Drug Testing and Analysis·Hamilton Morris, Jason Wallach
Dec 17, 2014·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Paul DominiciAdam Rowden
Feb 24, 2015·Journal of Pharmacological Sciences·Jeong Min KimYoung Min Bae
Oct 16, 2015·Journal of Neurosurgical Anesthesiology·Frederick A ZeilerColin J Kazina

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.