PMID: 6973001Jun 1, 1981Paper

Multiple activities of a cloned cell line mediating natural killer cell function

The Journal of Experimental Medicine
G NabelH Cantor

Abstract

A special class of immunologic cells can lyse or damage a variety of target cells, notably malignant cells in vitro. These cells have been called natural killer (NK) cells because lysis does not require deliberate immunization by tumor cells. Although these cells can be distinguished from conventional T cells, B cells, and phagocytic cells, they have been difficult to define. We describe a representative cloned cell line that was obtained by cloning Ig -Ly-5+ cells from spleen. This clone, Cl.Ly-1-2-NK-1+/11, displays Thy-1, Ly-5, Qat-4, Qat-5 and NK-1 cell surface antigens and lyses the NK-sensitive YAC-1 lymphoma cells, but does not lyse RL-12 cells, an NK-resistant lymphoma. In addition, this clone lysed the P815 mastocytoma, EL4 lymphoma, and lipopolysaccharide-activated B lymphocyte targets. This cloned population therefore combined information for a unique display of cell surface antigens and specialized function similar to "activated" NK cells. Because this cloned population forms conjugates with susceptible but not resistant target cells, it may prove useful to identify the structure of cell surface molecules that recognize foreign cells. Finally, cells of this clone also specificity lysed target cells coated by antibod...Continue Reading

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Citations

Jan 1, 1983·Cancer Metastasis Reviews·R K Oldham
Jan 1, 1984·Immunology Letters·N Schaaf-LafontaineG Degiovanni
Aug 1, 1989·Immunology and Cell Biology·Y C SmartR C Burton
Oct 1, 1989·Immunology and Cell Biology·R C BurtonH J Winn
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G J FreemanH Cantor
Nov 1, 1982·The Journal of Cell Biology·S J GalliH F Dvorak
Aug 1, 1982·The Journal of Experimental Medicine·G NabelH Cantor
Jul 1, 1985·The Journal of Experimental Medicine·R B SchwadronS Strober
Aug 1, 1985·The Journal of Experimental Medicine·K OshimiH Mizoguchi
Apr 1, 1986·The Journal of Experimental Medicine·P D ShahD A Rowley
Oct 1, 1987·The Journal of Experimental Medicine·B Hertel-WulffS Strober
Jan 1, 1983·Journal of Clinical Immunology·M FerrariniC E Grossi
Jun 30, 1983·Annals of the New York Academy of Sciences·D M ParrottH S Micklem
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Jan 1, 1986·Journal of Cellular Biochemistry·J D Young, Z A Cohn

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