PMID: 9660072Jul 11, 1998Paper

Multiple alignment comparison of the non-structural genes of influenza A viruses

Virus Research
David L Suarez, M L Perdue

Abstract

One hundred and six influenza A virus isolates were compared phylogenetically using gene segment 8 which encodes the two non-structural (NS) proteins, NS1 and NS2. The isolates separated into two previously described subtypes, A and B. For non-structural gene subtype A viruses, five subdivisions were distinguished in the nucleotide phylogenetic tree including a human-swine group, American avian-equine group, Eurasian avian-swine group, a unique gull isolate group, and a group with a single member, A/Equine/Prague/56. At the nucleotide sequence level the B subtype was subdivided into two groups, including the American avian group and Eurasian avian-equine group. In the analysis of the NS1 and NS2 predicted amino acid sequence, American and Eurasian influenza isolates became less distinguishable. Size variability of the NS1 protein was observed, especially in the human and swine isolates. The previously reported deletion in A/Turkey/Oregon/71 NS1 gene, which caused a truncated NS1 protein, was contrasted with a full length NS1 gene cloned from an earlier A/Turkey/Oregon/71 stock. All avian origin influenza viruses had a putative NS1 sequence length of 230 aa, with two exceptions, A/CK/Pennsylvania/1370/83 and A/CK/Pennsylvania/21...Continue Reading

References

Dec 1, 1992·The Journal of General Virology·E Hatada, R Fukuda
Jun 1, 1987·Virology·K NakajimaS Nakajima
Jan 1, 1995·Archives of Virology·A C WardI G Macreadie

❮ Previous
Next ❯

Citations

Aug 2, 2000·Trends in Microbiology·Z Chen, R M Krug
Jun 30, 2004·Avian Pathology : Journal of the W.V.P.A·Chang-Won LeeDavid L Suarez
Nov 8, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Christopher P Malinoski, Philip I Marcus
Feb 15, 2005·Journal of Virology·Ron A M FouchierAlbert D M E Osterhaus
Feb 15, 2005·Journal of Virology·Philip I MarcusMargaret J Sekellick
Jan 25, 2014·BMC Evolutionary Biology·Lu LuAndrew J Leigh Brown
Oct 22, 2014·Nucleic Acids Research·Mathieu MétifiotMarie-Line Andreola
Jan 24, 2014·Critical Reviews in Microbiology·Audrey ArnalElsa Jourdain
Feb 24, 2016·Viral Immunology·Noor Haliza HasanFarhid Hemmatzadeh
Nov 25, 2011·Veterinary Microbiology·Ana MorenoPaolo Cordioli
Oct 26, 2010·Virus Research·Hatice AkarsuYoshihiro Kawaoka
Nov 7, 2008·Veterinary Microbiology·Leyi Wang, Chang-Won Lee
Sep 18, 2008·The Journal of General Virology·Benjamin G HaleDavid Jackson
Sep 21, 2013·Virulence·E M AbdelwhabThomas C Mettenleiter
Jul 1, 2008·Virology·Benjamin G HaleRupert J Russell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.