PMID: 9428007Jan 15, 1998Paper

Multiple alpha 2-adrenoceptor signalling pathways mediate pigment aggregation within melanophores

Pigment Cell Research
S P SvenssonJ O Karlsson

Abstract

It has previously been shown that alpha 2-adrenoceptors (alpha 2-ARs) mediate pigment granule (melanosome) aggregation in melanophores of the teleost fish Labrus ossifagus. The present investigation scrutinized the signalling mechanisms of melanosome aggregation induced by sympathetic nerve stimulation or by exogenous addition of alpha-AR agonists and cAMP analogues. The following was observed: i) nerve-induced melanosome aggregation was associated with a rapid decrease in the cAMP level; ii) noradrenaline or medetomidine (an alpha 2-AR agonist) caused melanosome aggregation and reduced the cAMP content; iii) RP-8-Cl-cAMP, a membrane-permeating inhibitor of protein kinase A induced melanosome aggregation; and iv) B-HT 920 (an alpha 2-AR agonist) and methoxamine (an alpha 1-AR agonist) induced melanosome aggregation, although they did not reduce cAMP. It has been suggested that in some teleost species alpha 1-ARs mediate melanosome aggregation by increasing the level of intracellular calcium. However, we found that the effect of methoxamine in melanophores from Labrus ossifagus could be blocked by yohimbine (an alpha 2-AR antagonist) but not by equimolar concentration of prazosin (an alpha 1-AR antagonist). Furthermore, 1 microM...Continue Reading

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Citations

Feb 8, 2000·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·E FabbriA Capuzzo
Oct 25, 2003·Cellular Signalling·Tony P M AnderssonSamuel P S Svensson
Feb 19, 2002·Biosensors & Bioelectronics·Annika M KarlssonSamuel P S Svensson
Nov 26, 1998·Biosensors & Bioelectronics·I Lundström, S Svensson
Sep 6, 2002·Pigment Cell Research·Helén Nilsson SköldMargareta Wallin
Sep 5, 2002·Bioelectromagnetics·Martin F TestorfShoogo Ueno
Dec 7, 2006·Journal of Neuroscience Research·Sara AspengrenMargareta Wallin
Oct 26, 2012·Journal of Receptor and Signal Transduction Research·Saima SalimSharique A Ali
May 3, 2015·Molecular and Cellular Endocrinology·João C R CardosoDeborah M Power
Oct 21, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Elena Fabbri, Thomas W Moon
Jan 6, 2009·International Review of Cell and Molecular Biology·Sara AspengrenMargareta Wallin

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