PMID: 2500658Jul 1, 1989Paper

Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium

Proceedings of the National Academy of Sciences of the United States of America
M PupilloP N Devreotes

Abstract

Previous results have shown that chemotaxis and the expression of several classes of genes in Dictyostelium discoideum are regulated through a cell surface cAMP receptor interacting with guanine nucleotide-binding proteins (G proteins). We now describe cloning and sequencing of cDNAs encoding two G alpha protein subunits from Dictyostelium. The derived amino acid sequences show that they are 45% identical to each other and to G alpha protein subunits from mammals and yeast. Both cDNAs are complementary to multiple mRNAs that are differentially expressed during development. This evidence and analysis of mutants presented elsewhere suggest that they have distinct physiological functions.

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Citations

Jan 1, 1991·Developmental Genetics·D J PetersP Schaap
Jan 1, 1991·Developmental Genetics·K L Fosnaugh, W F Loomis
Dec 1, 1994·Plant Molecular Biology·H Ma
Mar 1, 1992·Cancer Metastasis Reviews·J CondeelisJ E Segall
Dec 18, 1995·Experientia·C D ReymondJ G Williams
Jan 1, 1991·Pharmacology & Therapeutics·J Olate, J E Allende
Mar 21, 2001·Biochimica Et Biophysica Acta·A Rupper, J Cardelli
Oct 24, 2002·Development, Growth & Differentiation·Maureen A BrandonGregory J Podgorski
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H MaE M Meyerowitz
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J A HadwigerR A Firtel
Apr 1, 1995·The Journal of Cell Biology·M KreitmeierA Müller-Taubenberger
Jun 1, 1994·Molecular Biology of the Cell·R H InsallP N Devreotes
Sep 11, 1991·Nucleic Acids Research·A SwaroopS M Weissman
Oct 13, 2001·The Journal of Eukaryotic Microbiology·M J MarinoD C Wood
Dec 1, 1994·Plant Molecular Biology·A L Drayer, P J van Haastert
Mar 1, 1994·Mathematical Biosciences·Y Tang, H G Othmer
May 23, 2007·The Journal of Cell Biology·Ineke Keizer-GunninkPeter J M Van Haastert
Mar 6, 1992·Cell·C H Berlot, H R Bourne
Nov 5, 1997·The Journal of Investigative Dermatology·B M RockJ N Wilcox
Dec 2, 2000·Differentiation; Research in Biological Diversity·K NatarajanJ A Hadwiger
Apr 1, 1995·Differentiation; Research in Biological Diversity·J BluschW Nellen
Sep 30, 1991·Biochemical and Biophysical Research Communications·L J Wu, P N Devreotes
Jul 16, 1991·Biochemistry·R L JohnsonP N Devreotes

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