PMID: 8964916May 1, 1996Paper

Multiple antibodies to nerve glycoconjugates in a patient with neuropathy and monoclonal IgA gammopathy

Journal of Neuroimmunology
R G FarrerR H Quarles

Abstract

Several immunological abnormalities were found in a patient with mixed axonal and demyelinating neuropathy in association with a prominent monoclonal IgA lamda band in his serum. He had antibodies to the major LM1 ganglioside of human nerve that were restricted to the IgA class, but they were polyclonal and distinct from the major monoclonal IgA component. He also had a low level of a monoclonal IgM lamda antibody to the myelin-associated glycoprotein and sulfate-3-glucuronyl paragloboside that was not detected by routine immunofixation. The observations made on this complex patient, are presented in the context of emphasizing that immunological reactivities to neural antigens that are not due to the principal monoclonal antibody may be present in patients with neuropathy in association with gammopathy.

References

Nov 21, 1991·The New England Journal of Medicine·P J DyckB A Evans
Jan 1, 1992·Journal of Neuroimmunology·A A IlyasS D Cook
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A A IlyasR O Brady
Sep 1, 1989·Postgraduate Medical Journal·T HemachudhaS Kasempimolporn
Jan 1, 1989·Methods in Enzymology·R H Quarles
Apr 1, 1986·Acta Neurologica Scandinavica·S Dhib-Jalbut, B H Liwnicz
Jun 1, 1986·Acta Neurologica Scandinavica·R O BaileyA Y Wu
May 1, 1988·Annals of Neurology·A A IlyasG M McKhann
Oct 1, 1973·Journal of Neurochemistry·R W LedeenL F Eng
Feb 1, 1984·Neurology·E Nobile-OrazioA Tahmoush
Jul 1, 1981·Annals of Neurology·M C Dalakas, W K Engel

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Citations

Sep 16, 2010·Current Treatment Options in Neurology·Marinos C Dalakas
Jul 21, 1998·Annals of the New York Academy of Sciences·R K Yu, T Ariga
Feb 7, 2018·Therapeutic Advances in Neurological Disorders·Marinos C Dalakas

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