Multiple anxiogenic drugs recruit a parvalbumin-containing subpopulation of GABAergic interneurons in the basolateral amygdala.

Progress in Neuro-psychopharmacology & Biological Psychiatry
M W HaleC A Lowry

Abstract

The basolateral amygdala is a nodal structure within a distributed and interconnected network that regulates anxiety states and anxiety-related behavior. Administration of multiple anxiogenic drugs increases cellular responses (i.e., increases c-Fos expression) in a subregion of the basolateral amygdala, but the neurochemical phenotypes of these cells are not known. The basolateral amygdala contains glutamatergic projection neurons and several populations of γ-aminobutyric acid-synthesizing (GABAergic) interneurons, including a population of parvalbumin (PV)-expressing GABAergic interneurons that co-express the excitatory 5-HT(2A) receptor. The role for these PV-expressing GABAergic interneurons in anxiety-states is unclear. In this experiment we examined the effects of multiple anxiogenic drugs including the 5-HT(2C/2A) receptor agonist m-chlorophenyl piperazine (mCPP), the adenosine receptor antagonist caffeine, the α(2)-adrenoreceptor antagonist yohimbine and the partial inverse agonist at the benzodiazepine allosteric site on the GABA(A) receptor, N-methyl-beta-carboline-3-carboxamide (FG-7142), on c-Fos expression in PV-immunoreactive (PV-ir) interneurons in subdivisions of the basolateral amygdala. All drugs with the exce...Continue Reading

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Citations

Mar 16, 2013·Histochemistry and Cell Biology·Esther AsanKlaus-Peter Lesch
Oct 6, 2011·Social Cognitive and Affective Neuroscience·Jessica E SmithPeter J Rogers
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Klaus-Peter LeschLise Gutknecht
Apr 4, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Triin TekkoEero Vasar
Feb 22, 2014·Cellular and Molecular Neurobiology·Debapriya Garabadu, Sairam Krishnamurthy
Sep 11, 2010·Physiology & Behavior·Lotte C HoutepenChristiaan H Vinkers
Aug 19, 2014·Genes, Brain, and Behavior·T ChachuaL Velíšek
Apr 10, 2018·Experimental & Molecular Medicine·Olga BabaevDilja Krueger-Burg
Sep 11, 2018·The Journal of Pharmacy and Pharmacology·Yadavalli ChandrasekharKandangath Raghavan Anilakumar
Jun 27, 2017·Molecular Autism·Tiffany D RogersJeremy Veenstra-VanderWeele
Jun 1, 2017·Journal of Behavioral Addictions·Gustavo C MedeirosJon E Grant
Jun 10, 2017·Brain Structure & Function·Amy E B PackardYvonne M Ulrich-Lai
Aug 10, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laverne C MelónJamie L Maguire

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