Multiple B cell stimulation by individual antigen-specific T lymphocytes

European Journal of Immunology
S K Pierce, N R Klinman

Abstract

Recently, an experimental system has been described which allows for the isolation and antigenic stimulation of individual antigen-specific helper T lymphocytes in collaboration with a nonlimiting number of primary B lymphocytes. In the studies presented in this report, this system has been employed to determine whether an individual T lymphocyte has the potential to interact with more than a single B lymphocyte, when the B cells are of different antigenic specificities. The results of these studies indicate that an individual influenza virus PR 8-specific T lymphocyte has the ability to promote antibody responses of both trinitrophenyl (TNP)- and PR8-specific B lymphocytes in response to the in vitro antigen TNP-PR8. Similar results were obtained when T cells specific for the hapten TNP were used in collaboration with TNP- and PR8-specific B cells. These results demonstrate that an individual T lymphocyte has the potential to collaborate with more than one B lymphocyte, and that these B cells may differ in their antibody receptor for antigen. These results do not rule out a role for idiotype or allotype-specific T cells in antibody responses but, rather, strongly argue that antigen-specific T cells are able to independently in...Continue Reading

References

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Citations

Feb 1, 1982·The Journal of Experimental Medicine·N A Speck, S K Pierce
Jun 1, 1982·Cancer Treatment Reviews·C S Foster
Jan 1, 1983·Annals of the New York Academy of Sciences·S K Pierce, N A Speck
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hayato TakahashiMasayuki Amagai

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