Abstract
We report a 22-year-old Japanese woman with multiple basaloid cell hamartoma with alopecia and autoimmune disease (systemic lupus erythematosus). She presented with infiltrated large annular, brown-violet, erythematous plaques with atrophic areas in the center on her right cheek, left abdomen and left knee. She also had progressive multiple follicular keratotic papules on her scalp, face, neck, and both axilla and hair loss from her scalp, eyebrow, and axilla. Serologically, rheumatoid factor (+ + +), rheumatoid arthritis hemagglutination test (x1280), and anti-nuclear antigen (x160) were positive. Histological findings of the annular lesion showed liquefaction degeneration of basal cells, lymphocytic infiltration around hair follicles and capillaries, and panniculitis with lymphoid cell infiltration, which was diagnosed as lupus erythematosus profundus. The histological findings of multiple follicular papular lesions of the scalp and neck showed aggregations of basaloid cells, partially with hair-bulb-like structures, which was diagnosed as trichoepithelioma. Taken together, the histogenesis of multiple basaloid cell hamartoma is thought to share the same basis with autoimmune disease.
References
Aug 1, 1992·Journal of the American Academy of Dermatology·M H Brownstein
Aug 1, 1988·Journal of the American Academy of Dermatology·S MiyakawaM Sugawara
Nov 1, 1986·Journal of the American Academy of Dermatology·T M StarinkC J Meijer
Feb 1, 1985·Journal of Cutaneous Pathology·A H Mehregan, S Baker
Jan 1, 1981·Clinical and Experimental Dermatology·M PlosilaK M Niemi
May 1, 1981·Clinical and Experimental Dermatology·C M Ridley, N Smith
Aug 1, 1993·Journal of Cutaneous Pathology·E Alessi, A Azzolini
Citations
Oct 20, 2004·The Journal of Dermatology·Kenta TsuruMasato Ueda
May 28, 2010·Journal of Cutaneous Pathology·Alireza SepehrSteven R Tahan
May 15, 2010·International Journal of Dermatology·Xi-chuan YangBai-yu Zhong
Sep 24, 2005·Clinics in Dermatology·Uwe Wollina, Gert Hein
Nov 9, 2000·The British Journal of Dermatology·H ShimizuM Ueda
Apr 11, 2008·Journal of Cutaneous Pathology·Frances I Ramos-CeballosBruce R Smoller
Jun 2, 1998·Lupus·S MortonR J Powell
Jul 18, 2002·The Australasian Journal of Dermatology·Steven Kossard
Jan 12, 2007·Journal of Cutaneous Pathology·L L BraileyS M Ruhoy
Sep 1, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Aradhna SaxenaJ Ramsey Mellette
Mar 26, 2003·The American Journal of Dermatopathology·Debra M JihJohn T Seykora
Mar 31, 2012·Ophthalmic Plastic and Reconstructive Surgery·Frederick A JakobiecNancy Kim
Jun 28, 2018·American Journal of Clinical Dermatology·Siriorn UdompanichPoonkiat Suchonwanit
Aug 18, 2020·American Journal of Ophthalmology Case Reports·Nicole JedrzynskiMichael Kazim
Jan 30, 2019·Annales de dermatologie et de vénéréologie·G HazemannB Cribier
Jun 17, 2021·The American Journal of Dermatopathology·Ijeuru ChikekaViktoryia Kazlouskaya