Multiple Beneficial Effects of Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension

Circulation Journal : Official Journal of the Japanese Circulation Society
Shunsuke TatebeHiroaki Shimokawa

Abstract

Pulmonary arterial hypertension with systemic dysfunctions, including metabolic disorders and renal dysfunction, has a poor prognosis. However, it remains to be elucidated whether chronic thromboembolic pulmonary hypertension (CTEPH) is also associated with systemic dysfunctions, and if so, whether balloon pulmonary angioplasty (BPA) improves them. Fifty-five consecutive patients who underwent BPA from March 2012 to December 2014 for systemic dysfunctions, including glycemic control, lipid profiles, renal and vascular function, and nutritional status were examined. The analyses were performed before and after BPA (mean, 3.5 sessions/patient) and changes in hemodynamic parameters were compared. The average follow-up period was 474±245 days. Baseline prevalence of hypertension, diabetes mellitus, dyslipidemia and advanced chronic kidney disease was 58, 7, 33 and 36%, respectively. BPA caused marked hemodynamic improvements in the CTEPH patients. Importantly, BPA also significantly improved dysglycemia (fasting blood sugar, hemoglobin A1c and homeostatic assessment model of insulin resistance), renal (creatinine and estimated glomerular filtration rate) and vascular (cardio-ankle vascular index) functions and nutritional status (a...Continue Reading

References

Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Marc HumbertGérald Simonneau
May 31, 2006·Journal of Atherosclerosis and Thrombosis·Kohji ShiraiMasanobu Takata
Aug 19, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Branislav RadovancevicO H Frazier
Jun 17, 2008·American Journal of Respiratory and Critical Care Medicine·Angelo G CorsicoMario Viganò
Oct 22, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Ayako ShigetaTakayuki Kuriyama
Nov 15, 2008·Journal of the American College of Cardiology·Claudio RoncoRinaldo Bellomo
Dec 3, 2008·The European Respiratory Journal·R T ZamanianR L Doyle
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
May 8, 2010·American Journal of Respiratory and Critical Care Medicine·Gustavo A HeresiRaed A Dweik
May 27, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Shunsuke TatebeHiroaki Shimokawa
Mar 29, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Jul 13, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiro Fukumoto, Hiroaki Shimokawa
Dec 22, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichiro SugimuraHiroaki Shimokawa
Mar 2, 2012·European Respiratory Review : an Official Journal of the European Respiratory Society·N H Kim, I M Lang
Nov 30, 2012·Circulation. Cardiovascular Interventions·Hiroki MizoguchiHiromi Matsubara
Dec 19, 2012·Nature Reviews. Nephrology·Parta HatamizadehKamyar Kalantar-Zadeh
Feb 7, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Shunsuke TatebeHiroaki Shimokawa
Apr 26, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Rintaro NishimuraKoichiro Tatsumi
Nov 29, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Shigeo YamakiHiroaki Shimokawa
Mar 15, 2014·The European Respiratory Journal·Shigefumi FukuiNorifumi Nakanishi
Sep 17, 2014·International Journal of Cardiology·Masayuki MizunoUNKNOWN Acute Decompensated Heart Failure Syndromes [ATTEND] investigators
Aug 21, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroto ShimokawaharaMasahiro Sonoda

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Citations

Mar 11, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Toru Satoh
Apr 22, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Haruka SatoHiroaki Shimokawa
May 14, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Norikazu Yamada
Jul 5, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Masafumi FukumitsuMasaru Sugimachi
Aug 3, 2016·The Cochrane Database of Systematic Reviews·Andrew J WardleJ Simon R Gibbs
Oct 22, 2016·Circulation. Cardiovascular Interventions·Jane A Leopold
Apr 27, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Kimio Satoh, Hiroaki Shimokawa
Mar 31, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Joanna Pepke-ZabaMarius M Hoeper
Dec 25, 2019·Cardiovascular Intervention and Therapeutics·Nobutaka Ikeda
Jul 14, 2020·Current Opinion in Pulmonary Medicine·Vikramjit S Khangoora, Oksana A Shlobin
Sep 10, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Steffen D KriechbaumChristoph Liebetrau
Dec 20, 2018·International Journal of Molecular Sciences·Kimio SatohHiroaki Shimokawa
Apr 17, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Steffen D KriechbaumChristoph Liebetrau
May 23, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Kimio SatohHiroaki Shimokawa
Oct 11, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Kimio Satoh
Jul 25, 2018·Cardiovascular and Interventional Radiology·J M MoriartyR Saggar
Jun 25, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Giacomo ZoppellaroVittorio Pengo
Mar 6, 2021·Interventional Cardiology·John G CoghlanStephen P Hoole
Sep 6, 2019·Mayo Clinic Proceedings. Innovations, Quality & Outcomes·Vidhu AnandGurpreet S Sandhu

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