Multiple bicyclic diamide-lutetium complexes in solution: chemometric analysis of deep-UV Raman spectroscopic data

Inorganic Chemistry
Victor A ShashilovIgor K Lednev

Abstract

The investigation of complex formation between a bicyclic diamide, a novel chelating agent for lanthanides and actinides, and lutetium in an acetonitrile solution is reported. A free ligand and its lutetium complexes showed weak, noncharacteristic near-UV absorption and no fluorescence, which limited the application of absorption and fluorescence spectroscopies for studying this system. Deep-UV Raman spectroscopy combined with chemometric analysis was shown to be a powerful tool for quantitative characterization of multiple equilibria between lutetium and a bicyclic diamide. Several chemometric methods were utilized for a comparative analysis of Raman spectroscopic data. It was found that a recently developed stepwise maximum angle calculation algorithm followed by alternative least squares (ALS) was more efficient than the commonly used combination of evolving factor analysis and ALS methods, especially when little or no information about the system composition and the spectra of individual components was available. A free ligand and 1:1, 1:2, and 1:3 metal-ligand complexes were distinguished in a bicyclic diamide-lutetium solution. The composition evolution of the solution during the course of titration with lutetium was desc...Continue Reading

References

May 16, 2002·Journal of the American Chemical Society·Gregg J LumettaJames E Hutchison
Dec 31, 2004·Analytical and Bioanalytical Chemistry·Igor K LednevMing Xu
Jul 13, 2006·The Journal of Physical Chemistry. a·Victor A ShashilovIgor K Lednev

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.