Multiple binding sites for transcriptional repressors can produce regular bursting and enhance noise suppression

Physical Review. E
Iván M Lengyel, Luis G Morelli

Abstract

Cells may control fluctuations in protein levels by means of negative autoregulation, where transcription factors bind DNA sites to repress their own production. Theoretical studies have assumed a single binding site for the repressor, while in most species it is found that multiple binding sites are arranged in clusters. We study a stochastic description of negative autoregulation with multiple binding sites for the repressor. We find that increasing the number of binding sites induces regular bursting of gene products. By tuning the threshold for repression, we show that multiple binding sites can also suppress fluctuations. Our results highlight possible roles for the presence of multiple binding sites of negative autoregulators.

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Citations

Jan 19, 2018·Journal of the Royal Society, Interface·Zhipeng WangPeter G Wolynes
May 20, 2018·Physical Review. E·David J JörgFrank Jülicher
Nov 1, 2018·Nucleic Acids Research·Jorge Val-CalvoWilfried J J Meijer
Jan 20, 2018·Physical Review. E·David J Jörg

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