Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures

The Journal of Biological Chemistry
M I UzelP C Trackman

Abstract

Lysyl oxidase catalyzes the final enzymatic step required for collagen and elastin cross-linking in extracellular matrix biosynthesis. Pro-lysyl oxidase is processed by procollagen C-proteinase activity, which also removes the C-propeptides of procollagens I-III. The Bmp1 gene encodes two procollagen C-proteinases: bone morphogenetic protein 1 (BMP-1) and mammalian Tolloid (mTLD). Mammalian Tolloid-like (mTLL)-1 and -2 are two genetically distinct BMP-1-related proteinases, and mTLL-1 has been shown to have procollagen C-proteinase activity. The present study is the first to directly compare pro-lysyl oxidase processing by these four related proteinases. In vitro assays with purified recombinant enzymes show that all four proteinases productively cleave pro-lysyl oxidase at the correct physiological site but that BMP-1 is 3-, 15-, and 20-fold more efficient than mTLL-1, mTLL-2, and mTLD, respectively. To more directly assess the roles of BMP-1 and mTLL-1 in lysyl oxidase activation by connective tissue cells, fibroblasts cultured from Bmp1-null, Tll1-null, and Bmp1/Tll1 double null mouse embryos, thus lacking BMP-1/mTLD, mTLL-1, or all three enzymes, respectively, were assayed for lysyl oxidase enzyme activity and for accumulat...Continue Reading

References

Jan 1, 1979·International Review of Connective Tissue Research·R C Siegel
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Sep 1, 1991·American Journal of Respiratory Cell and Molecular Biology·H M Kagan, P C Trackman
Mar 1, 1982·Analytical Biochemistry·R Vytásek
Feb 15, 1995·The Biochemical Journal·A D CronshawD J Hulmes
Jan 1, 1995·Methods in Enzymology·H M Kagan, P Cai
Jan 19, 1996·Science·E KesslerD S Greenspan
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·S W LiD J Prockop
Apr 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·D J HulmesE Kessler
May 22, 1998·Trends in Genetics : TIG·M C Mullins
Apr 23, 1999·The Journal of Biological Chemistry·C Jourdan-Le SauxK Csiszar
Jul 27, 1999·The Journal of Biological Chemistry·H Nagase, J F Woessner
May 12, 2000·The Journal of Biological Chemistry·S AmanoR E Burgeson
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M I UzelP C Trackman
Jul 18, 2000·The Journal of Biological Chemistry·I C ScottD S Greenspan

❮ Previous
Next ❯

Citations

May 22, 2009·Calcified Tissue International·N PischonP C Trackman
Mar 20, 2013·Calcified Tissue International·David R Eyre, Mary Ann Weis
Dec 31, 2010·Journal of Neural Transmission·Karlo M Lopez, Frederick T Greenaway
May 9, 2013·Journal of Neural Transmission·Lubica Dudakova, Katerina Jirsova
Nov 26, 2010·Inflammopharmacology· SiddikuzzamanC Guruvayoorappan
Apr 25, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Qian Xiao, Gaoxiang Ge
Jan 11, 2014·Archives of Biochemistry and Biophysics·Joel FinneyMinae Mure
Jun 14, 2005·Biochimica Et Biophysica Acta·Junji OhnishiTakayuki Takahashi
Jan 30, 2010·Injury·Richard Marsell, Thomas A Einhorn
Mar 3, 2010·Biochemistry·Siddharth R VoraPhilip C Trackman
Jul 20, 2012·Nature Reviews. Cancer·Holly E BarkerJanine T Erler
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Masahito HoriguchiTomoyuki Nakamura
Jul 21, 2009·The Journal of Biological Chemistry·Guorui HuangDaniel S Greenspan
Jan 6, 2010·The Journal of Biological Chemistry·Siddharth R VoraPhilip C Trackman
Feb 26, 2010·The Journal of Biological Chemistry·Takumi MaruhashiAkira Kudo
Oct 27, 2011·The Journal of Biological Chemistry·Alison Muir, Daniel S Greenspan
Apr 27, 2012·Genetic Testing and Molecular Biomarkers·Jie WuHongchun Hou
Apr 2, 2010·Biology of Reproduction·Elizabeth Canty-LairdStéphane Fabre
Jun 19, 2007·Plastic and Reconstructive Surgery·Steven L HenryAlberto A Diaz-Arias
Jun 22, 2013·Investigative Ophthalmology & Visual Science·Tara Tovar-VidalesRobert J Wordinger
Jan 13, 2006·Acta Microbiologica Et Immunologica Hungarica·Tze-Jou Annie YehR M Friedman
Jan 10, 2002·Analytical Biochemistry·Amitha H Palamakumbura, Philip C Trackman
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gaoxiang GeDaniel S Greenspan
Jan 15, 2014·Human Molecular Genetics·Alison M MuirDaniel S Greenspan
Sep 13, 2012·Current Eye Research·Karunakaran CoralNarayanasamy Angayarkanni
May 20, 2011·Connective Tissue Research·Phimon AtsawasuwanMitsuo Yamauchi
Oct 27, 2015·International Journal of Molecular Medicine·Anjali Sharma-BhandariYoungho Kim
Sep 19, 2015·Biochimie·Sylvie Ricard-Blum, Sylvain D Vallet
Nov 6, 2015·Calcified Tissue International·Loai AlsofiPhilip C Trackman
Jan 17, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Philip C Trackman
Jul 6, 2010·Protein Expression and Purification·Sanna E HerwaldKarlo M Lopez
Dec 23, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Takako SasakiKlaus von der Mark
Feb 6, 2016·Expert Opinion on Therapeutic Targets·Philip C Trackman
Oct 8, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Rajeev BoregowdaTimothy M Ritty
May 10, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Caroline ReynaudPascal Sommer

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.