Multiple-breath washin of helium and sulfur hexafluoride in sustained microgravity

Journal of Applied Physiology
G Kim PriskJ B West

Abstract

We performed multiple-breath washouts of N2 and simultaneous washins of He and SF6 with fixed tidal volume (approximately 1,250 ml) and preinspiratory lung volume (approximately the subject's functional residual capacity in the standing position) in four normal subjects (mean age 40 yr) standing and supine in normal gravity (1 G) and during exposure to sustained microgravity (microG). The primary objective was to examine the influence of diffusive processes on the residual, nongravitational ventilatory inhomogeneity in the lung in microG. We calculated several indexes of convective ventilatory inhomogeneity from each gas species. A normal degree of ventilatory inhomogeneity was seen in the standing position at 1 G that was largely unaltered in the supine position. When we compared the standing position in 1 G with microG, there were reductions in phase III slope in all gases, consistent with a reduction in convection-dependent inhomogeneity in the lung in microG, although considerable convective inhomogeneity persisted in microG. The reductions in the indexes of convection-dependent inhomogeneity were greater for He than for SF6, suggesting that the distances between remaining nonuniformly ventilated compartments in microG were...Continue Reading

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Citations

May 18, 2001·Journal of Applied Physiology·K C Beck, T A Wilson
Jul 24, 2001·Medical & Biological Engineering & Computing·N O Strömberg
Jan 18, 2002·Journal of Applied Physiology·Mikael GrönkvistPer M Gustafsson
Dec 10, 2002·Journal of Applied Physiology·Mikael GronkvistPer M Gustafsson
Apr 20, 2004·Journal of Applied Physiology·I Mark Olfert, G Kim Prisk
Dec 17, 2011·Journal of Applied Physiology·Christopher R Stuart-AndrewsBruce R Thompson
Mar 26, 2016·Journal of Applied Physiology·Sylvia Verbanck, Manuel Paiva
Mar 2, 2019·The European Respiratory Journal·Jonathan H RaymentFelix Ratjen
Jan 29, 2019·Current Pathobiology Reports·G Kim Prisk
May 8, 1999·Journal of Applied Physiology·B DutrieueG K Prisk
Jul 25, 2000·Journal of Applied Physiology·G K Prisk
Feb 24, 2001·Journal of Applied Physiology·T A Wilson
Sep 2, 2003·Pediatric Pulmonology·Henrik K Ljungberg, Per M Gustafsson
Apr 2, 2005·Journal of Applied Physiology·G TusmanS H Böhm
Aug 20, 2019·The Medical Journal of Australia·G Kim Prisk
Mar 15, 2001·Journal of Applied Physiology·M J Rodríguez-NietoM Paiva
Oct 29, 2000·Journal of Applied Physiology·B DutrieueM Paiva
Oct 23, 2002·Journal of Applied Physiology·Brigitte DutrieueG Kim Prisk
Jul 5, 2012·Journal of Biomechanical Engineering·F S HenryR S Tepper
Dec 14, 2011·Journal of Applied Physiology·Sylvia VerbanckAlain Van Muylem
May 16, 2008·European Journal of Applied Physiology·G Kim PriskJohn B West
Oct 15, 2021·The Journal of Physiology·Sam BayatSylvia Verbanck

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