Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways

Journal of the American College of Cardiology
Xi-Ming YangMichael V Cohen

Abstract

An in situ model was used to test whether and how multiple occlusions at reperfusion can protect rabbit myocardium. Recently it was demonstrated that postconditioning in dogs salvaged ischemic myocardium. Control hearts underwent 30-min regional ischemia/3-h reperfusion, whereas in experimental hearts four postconditioning cycles of 30-s occlusion/30-s reperfusion starting 30 s after release of the index coronary occlusion were added in the presence or absence of various cell signaling antagonists. Postconditioning decreased infarction from 35.4 +/- 2.7% of the risk zone in control hearts to 19.8 +/- 1.8% (p < 0.05). Six cycles did not result in greater protection. If postconditioning cycles were begun after 10 min of reperfusion, protection was no longer evident. Either the non-selective K(ATP) channel closer glibenclamide or the putatively selective mitochondrial K(ATP) channel antagonist 5-hydroxydecanoate administered 5 min before reperfusion blocked the protection afforded by postconditioning, indicating involvement of the mitochondrial K(ATP) channel. PD98059, a mitogen-activated protein/extracellular-signal regulated kinase (MEK) 1/2 and therefore extracellular-signal regulated kinase (ERK) inhibitor, and N(omega)-nitro-...Continue Reading

References

Jul 1, 1987·Progress in Cardiovascular Diseases·L C Becker, G Ambrosio
Apr 1, 1993·Journal of the American College of Cardiology·A FarbR Virmani
May 1, 1996·Cardiovascular Research·R S Vander Heide, K A Reimer
Nov 1, 1996·The Annals of Thoracic Surgery·J ToddJ Vinten-Johansen
Aug 26, 1998·Cardiovascular Research·H M PiperM Ovize
May 1, 2001·Basic Research in Cardiology·R M FryerG J Gross
Feb 28, 2003·Journal of Molecular and Cellular Cardiology·Robert M Bell, Derek M Yellon
Jun 6, 2003·Journal of Molecular and Cellular Cardiology·Olaf OldenburgJames M Downey
Jul 16, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zhi-Qing ZhaoJakob Vinten-Johansen
Sep 6, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Olaf OldenburgJames M Downey
Nov 26, 2003·Journal of Cardiovascular Pharmacology·Shi Jun ZhangJames M Downey
Mar 11, 2004·Journal of Molecular and Cellular Cardiology·Xi-Ming YangMichael V Cohen

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Citations

May 25, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shaojian YeJialing Wang
Jan 2, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Han HuangJin Liu
Feb 5, 2009·Intensive Care Medicine·Ke-Xuan LiuZhengyuan Xia
Feb 22, 2005·Basic Research in Cardiology·Guro Valen, Jarle Vaage
Mar 29, 2005·Basic Research in Cardiology·J Vinten-JohansenF Kerendi
Feb 17, 2006·Basic Research in Cardiology·James M Downey, Michael V Cohen
Apr 11, 2006·Basic Research in Cardiology·Xi-Ming YangMichael V Cohen
Mar 29, 2006·Basic Research in Cardiology·Gerd HeuschRainer Schulz
Jul 11, 2006·Basic Research in Cardiology·Efstathios K IliodromitisDimitrios T Kremastinos
Sep 28, 2006·Basic Research in Cardiology·James MykytenkoZhi-Qing Zhao
May 29, 2007·Basic Research in Cardiology·Derek J HausenloyDerek M Yellon
Jun 5, 2007·Basic Research in Cardiology·Vivek SivaramanDerek M Yellon
Nov 14, 2007·Basic Research in Cardiology·Michael V Cohen, James M Downey
Feb 27, 2009·Basic Research in Cardiology·Derek J HausenloyDerek M Yellon
Jun 23, 2009·Basic Research in Cardiology·Andreas SkyschallyGerd Heusch
Aug 12, 2009·Basic Research in Cardiology·Xi-Ming YangMichael V Cohen
Sep 6, 2011·Basic Research in Cardiology·Yumei YeYochai Birnbaum
Jul 6, 2006·Apoptosis : an International Journal on Programmed Cell Death·He-Ying SunZhi-Qing Zhao
Jan 9, 2009·Apoptosis : an International Journal on Programmed Cell Death·YuZhen LiXiuHua Liu
Jun 10, 2010·Cardiovascular Drugs and Therapy·Zhi-Qing Zhao
Jun 2, 2007·Heart Failure Reviews·Derek J Hausenloy, Derek M Yellon
May 23, 2007·Heart Failure Reviews·Rainer SchulzGerd Heusch
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Heng Zhao
Jan 7, 2011·Cell Biochemistry and Biophysics·Jun ZhangChen Yuan
Oct 17, 2012·Cell Biochemistry and Biophysics·Eftychia DemeroutiEfstathios K Iliodromitis
Dec 8, 2010·Journal of Cardiovascular Translational Research·Santiago GarciaJay H Traverse
Oct 7, 2011·Archives of Pharmacal Research·Ankur RohillaAshok Kushnoor
Jan 1, 2012·Cardiovascular Intervention and Therapeutics·Yusuke UgataShinichi Momomura
Nov 14, 2013·Translational Stroke Research·Josef Anrather, John M Hallenbeck
May 12, 2005·Trends in Cardiovascular Medicine·Derek J HausenloyDerek M Yellon
Mar 8, 2008·Cardiology in the Young·Wanjun LuoRimao Huang

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